این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Basic Medical Sciences، جلد ۲۴، شماره ۱۰، صفحات ۱۳۰۷-۱۳۲۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Mesenchymal stem cells in cancer therapy; the art of harnessing a foe to a friend
چکیده انگلیسی مقاله For a long time, mesenchymal stem cells (MSCs) were discussed only as stem cells which could give rise to different types of cells. However, when it became clear that their presence in the tumor microenvironment (TME) was like a green light for tumorigenesis, they emerged from the ashes. This review was arranged to provide a comprehensive and precise description of MSCs’ role in regulating tumorigenesis and to discuss the dark and the bright sides of cancer treatment strategies using MSCs.To gather the details about MSCs, we made an intensive literature review using keywords, including MSCs, tumor microenvironment, tumorigenesis, and targeted therapy. Through transferring cytokines, growth factors, and microRNAs, MSCs maintain the cancer stem cell population, increase angiogenesis, provide a facility for cancer metastasis, and shut down the anti-tumor activity of the immune system. Although MSCs progress tumorigenesis, there is a consensus that these cells could be used as a vehicle to transfer anti-cancer agents into the tumor milieu. This feature opened a new chapter in MSCs biology, this time from the therapeutic perspective. Although the data are not sufficient, the advent of new genetic engineering methods might make it possible to engage these cells as Trojan horses to eliminate the malignant population. So many years of investigation showed that MSCs are an important group of cells, residing in the TME, studying the function of which not only could add a delicate series of information to the process of tumorigenesis but also could revolutionize cancer treatment strategies.
کلیدواژه‌های انگلیسی مقاله Carcinogenesis, Mesenchymal stem cells, Molecular targeted therapies, Neoplasm Tumor microenvironment
نویسندگان مقاله | Mehdi Karimi-Shahri
Department of Pathology, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran|Department of Pathology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Hossein Javid
Department of Medical Laboratory Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran|Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of ‎Medical Sciences, Mashhad, Iran


| Alireza Sharbaf Mashhad
Department of Medical Laboratory Sciences, Mashhad University of Medical Sciences, Mashhad, Iran


| Shaghayegh Yazdani
Department of Medical Laboratory Sciences, Ilam Institute for Medical Sciences, Ilam, Iran


| Seyed Isaac Hashemy
Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of ‎Medical Sciences, Mashhad, Iran|Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_18722.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Review Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات