این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Basic Medical Sciences، جلد ۲۴، شماره ۹، صفحات ۱۱۹۶-۱۲۰۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Gene expression of angiogenesis and apoptotic factors in female BALB/c mice with breast cancer after eight weeks of aerobic training
چکیده انگلیسی مقاله Objective(s): Breast cancer is the most common cancer in women, caused by a disorder in the angiogenesis and apoptosis process. Exercise can affect the process of angiogenesis and apoptosis in the tumor tissue. Thus, the aim of the present study was to investigate the changes in angiogenesis and apoptotic factors in mice with breast cancer after 8 weeks of exercise training.Materials and Methods: Sixteen females BALB/c mice (age: 3-5 weeks and weight: 17.1 ± 0.1 g) with breast cancer were randomly divided into two groups of aerobic training and control. The aerobic training included 8 weeks and 5 sessions per week of running with an intensity of 14-20 m.min-1. HIF-1α, VEGF, miR-21 and cytochrome C, Apaf-1, caspase-9, and caspase-3 gene expressions were examined by real-time PCR. Repeated measures ANOVA, Bonferroni’s post hoc test, and independent samples t-test were used to analyze the data (p < 0.05).Results: The results showed that aerobic training reduced the growth of tumor volume and significantly reduced miR-21 gene expression. Aerobic training also significantly increased the gene expression of HIF-1α, cytochrome C, Apaf-1, caspase-9, and caspase-3, while changes in VEGF gene expression were not statistically significant.Conclusion: It appears that aerobic exercise training reduces tumor size and ameliorates breast cancer by reducing miR-21 gene expression, suppressing the apoptosis process, and reducing angiogenesis.
کلیدواژه‌های انگلیسی مقاله aerobic exercise, Angiogenesis, Apoptosis, Breast Cancer, Gene expression
نویسندگان مقاله | Mohammad Mahdi Rafiei
Department of Sport Sciences, Kish International Campus, University of Tehran, Kish, Iran


| Raheleh Soltani
Department of Sport Sciences, Kish International Campus, University of Tehran, Kish, Iran


| Mohamadreza Kordi
Department of Exercise Physiology, Faculty of Sport Sciences, University of Tehran, Tehran, Iran


| Reza Nouri
Department of Sport Sciences, Kish International Campus, University of Tehran, Kish, Iran


| Abbasali Gaeini
Department of Exercise Physiology, Faculty of Sport Sciences, University of Tehran, Tehran, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_18590.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات