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Iranian Journal of Basic Medical Sciences، جلد ۲۴، شماره ۷، صفحات ۹۳۵-۹۴۲
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عنوان انگلیسی Urapidil alleviates ovarian torsion detorsion injury via regulating oxidative stress, apoptosis, autophagia, and inflammation
چکیده انگلیسی مقاله Objective(s): This study aimed to determine anti-inflammatory, antioxidant, and antiapoptotic properties of urapidil (Ura) against ovarian torsion detorsion (T/D) injury in rats. Materials and Methods: 40 female Wistar albino rats were grouped as sham, T/D, T/D+dimethyl sulfoxide (DMSO), T/D+Urapidil (Ura) 0.5 mg/kg (low dose), and T/D+Urapidil (Ura) 5 mg/kg (high dose) groups. In treatment groups, Ura was administered intraperitoneally just before detorsion. Biochemical parameters (TAS, TOS, MDA, MPO, and SOD) and immunohistochemical (IL-1β, TNF-α, NF-κB, LC3B, and Caspase-3) analyzes were performed.Results: In the T/D group, OSI and MPO levels were elevated significantly while TAS values decreased compared with the sham group. A significant difference occurred in the low dose treatment group in TAS and OSI levels compared with the T/D group. In the high dose treatment group, significant elevation in TAS but reduction in OSI and MDA levels were observed compared with the T/D group. Immunohistochemical staining resulted in IL-1β, TNF-α, NF-κB, LC3B, and caspase-3 immunopositivity in the T/D group, while Ura treatment decreased those parameters. Intensive congestion and hemorrhage were observed in the T/D group, but contrary to this, treatment groups had alleviated congestion and hemorrhage.Conclusion: These results suggest that Ura demonstrated protective effects against ovarian T/D injury via anti-oxidative, anti-inflammatory, and anti-apoptotic features. 
کلیدواژه‌های انگلیسی مقاله Autophagy, Caspase-3, Detorsion, NF-κB, Ovarian, Torsion, Urapidil
نویسندگان مقاله | Mustafa GULER
Department of Physiology, Atatürk University, Faculty of Medicine, Erzurum, Turkey


| Ayhan Tanyeli
Department of Physiology, Atatürk University, Faculty of Medicine, Erzurum, Turkey


| Derya GUZEL ERDOGAN
Department of Physiology, Sakarya University, Faculty of Medicine, Sakarya, Turkey


| Ersen Eraslan
Department of Physiology, Yozgat Bozok University, Faculty of Medicine, Yozgat, Turkey


| Selim Comakli
Department of Pathology, Atatürk University, Veterinary Faculty, Erzurum, Turkey


| Elif Polat
Department of Nutrition and Dietetics, Faculty of Health Sciences, Erzurum Technical University, Erzurum, Turkey


| Songul DOGANAY
Department of Physiology, Sakarya University, Faculty of Medicine, Sakarya, Turkey
نشانی اینترنتی https://ijbms.mums.ac.ir/article_18389.html
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