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Iranian Journal of Basic Medical Sciences، جلد ۲۴، شماره ۲، صفحات ۱۶۰-۱۶۶
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عنوان انگلیسی Cyanocobalamin improves memory impairment via inhibition of necrosis and apoptosis of hippocampal cell death after transient global ischemia/reperfusion
چکیده انگلیسی مقاله Objective(s): Brain ischemia/reperfusion (I/R) causes irreversible damage, particularly in the hippocampus. Cyanocobalamin (CNCbl) is known to be crucial for the proper operation of the nervous system. Vitamin B12 has been demonstrated to exert antioxidant effects via direct and indirect mechanisms. It can also protect cortical neurons against glutamate cytotoxicity. This research was conducted to examine CNCbl protection against neuronal cell death in the rat hippocampal region following transient cerebral ischemia.Materials and Methods: In this experiment, 48 male Wistar rats were selected, which were randomly divided into four groups (n=12 in each group): sham, ischemia/reperfusion, ischemia/reperfusion + CNCbl 200 and 400 (µg/kg). By occlusion of both common carotids, ischemia induction was performed within 20 min. CNCbl at the doses of 200 and 400 µg/kg was injected (IP) at the start of the reperfusion, 24 and 48 hr following reperfusion. The spatial memory was assessed 7 days following ischemia through the Morris water maze test. Antioxidant enzymes, apoptosis, and necrosis were measured after behavioral tests. Results: CNCbl significantly improved spatial memory impairments (p < 0.05), also CNCbl therapy significantly increased both glutathione (p < 0.01) and superoxide dismutase (p < 0.05) and reduced malondialdehyde (p < 0.01) and TNF-α (p < 0.05) in comparison with the ischemia group. In addition, CNCbl significantly decreased both apoptosis and necrosis in the hippocampus CA1 (p < 0.01).Conclusion: CNCbl improves memory impairment following ischemia injury by decreasing neuronal cell death via its antioxidant properties.
کلیدواژه‌های انگلیسی مقاله Apoptosis, Brain ischemia, Cyanocobalamin, Hippocampus, Memory, Necrosis
نویسندگان مقاله | Hossein Khastar
School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran


| Behzad Garmabi
Neurosciences Research Center, Shahroud University of Medical Sciences, Shahroud, Iran


| Fatemeh Zare Mehrjerdi
Neurobiomedical Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


| Mohamad Taghi Rahimi
School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran


| Nabi Shamsaei
Department of Sport Sciences, Ilam University, Ilam, Iran


| Amir-Hossein Ali
Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran


| Nilofar Khorsand
Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran


| Mehdi Khaksari
Neurosciences Research Center, Shahroud University of Medical Sciences, Shahroud, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_17314.html
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نوع مقاله منتشر شده Original Article
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