این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Basic Medical Sciences، جلد ۲۴، شماره ۱، صفحات ۵۸-۶۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Voluntary exercise improves spermatogenesis and testicular apoptosis in type 2 diabetic rats through alteration in oxidative stress and mir-34a/SIRT1/p53 pathway
چکیده انگلیسی مقاله Objective(s): This research was designed to demonstrate the impact of voluntary exercise on sperm parameters including sperm count, morphology, motility, viability, testicular apoptosis, oxidative stress, and the mir-34a/SIRT1/p53 pathway in type 2 diabetic rats.Materials and Methods: 32 Wistar male rats were separated into four groups: control (C), voluntary exercise (VE), diabetic (D), and diabetic rats that performed voluntary exercise (VED). To induce diabetes, animals were injected with streptozotocin (35 mg/kg) after receiving a high-fat diet. The testicular protein levels of SIRT1 and P53, miR-34a expression, MDA, GPx, SOD, catalase, and sperm parameters were evaluated.Results: Diabetes caused increased testicular MDA content, miR-34a expression, acetylated p53 protein expression, and the percent of immotile sperm (p Conclusion: It seems that voluntary exercise has significant positive impacts that can be employed to reduce the complications of type 2 diabetes in the testis of male rats.
کلیدواژه‌های انگلیسی مقاله Apoptosis miR, 34a Oxidative stress p53 Sperm parameters Type 2 diabetes Voluntary exercise
نویسندگان مقاله | Saber Ghaderpour
Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran


| Rafighe Ghiasi
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran|Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran


| Gholamreza Hamidian
Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran


| Hamed Heydari
Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran


| Rana Keyhanmanesh
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran|Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran|Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_17032.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات