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Iranian Journal of Basic Medical Sciences، جلد ۲۴، شماره ۱، صفحات ۸۵-۹۱
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عنوان انگلیسی Neurochemical effects of sleep deprivation in the hippocampus of the pilocarpine-induced rat model of epilepsy
چکیده انگلیسی مقاله Objective(s): The present study aims to investigate the pathological mechanisms mediating the effect of paradoxical sleep deprivation (PSD) for 48 hr on the spontaneous recurrent seizures (SRS) stage of the pilocarpine rat model of temporal lobe epilepsy. Materials and Methods: This was carried out through assessment of amino acid neurotransmitter levels, the main oxidative stress parameters, and the levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) in the hippocampus. The experimental animals were divided into 4 groups: control, epileptic, PSD, and epileptic+PSD groups.Results: Data indicated that PSD in epileptic rats induced a significant decrease in GSH levels. TNF-α increased significantly in the PSD group and decreased significantly in both epileptic rats and epileptic rats deprived of paradoxical sleep. PSD induced a significant increase in glutamine, glutamate, and aspartate and a significant decrease in GABA. In epileptic rats and epileptic rats deprived of PS, a significant increase in aspartate and a significant decrease in GABA and taurine were recorded. Conclusion: The present data suggest that exposure to PSD for 48 hr did not worsen the alterations produced in the present epileptic model. However, epileptic, PSD, epileptic + PSD groups showed a state of hyperexcitability and oxidative stress. PSD may increase the susceptibility of animals to the development of epilepsy. 
کلیدواژه‌های انگلیسی مقاله Amino acids, Cytokines, Epilepsy, Hippocampus, Oxidative stress, Sleep deprivation
نویسندگان مقاله | Heba Aboul Ezz
Zoology Department, Faculty of Science, Cairo University, Giza, Egypt


| Neveen Noor
Zoology Department, Faculty of Science, Cairo University, Giza, Egypt


| Iman Mourad
Zoology Department, Faculty of Science, Cairo University, Giza, Egypt


| Heba Fahmy
Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt


| Yasser Khadrawy
Medical Physiology Department, Medical Division, National Research Center, Giza, Egypt
نشانی اینترنتی https://ijbms.mums.ac.ir/article_17051.html
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