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Iranian Journal of Basic Medical Sciences، جلد ۲۳، شماره ۱۲، صفحات ۱۶۰۳-۱۶۰۹
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عنوان انگلیسی Effects of soy isoflavonoids (genistein and daidzein) on endometrial receptivity
چکیده انگلیسی مقاله Objective(s): This study aimed to examine the effects of genistein and daidzein on endometrial receptivity by histopathological, immunohistochemical, and biochemical techniques.Materials and Methods: In this study, 72 female Sprague-Dawley rats were randomly divided into 8 groups. The endometrial receptivity model was applied to identified groups. Experimental animals were given periorally 10 mg/kg and high 40 mg/kg doses of genistein and daidzein for 5 days by gavage. At the end of the experiment, uterine tissues were evaluated histopathologically, immunohistochemically, and biochemically. Results: When histopathological findings were examined, significant decreases in pinopod formation were observed in high dose genistein and daidzein groups. When compared with the endometrial receptivity group, immunohistochemical staining findings showed a significant decrease in the expression of integrin β3, integrin αvβ3, LIF, and HOXA10 and an increase in MUC 1 expression in the high dose of genistein and daidzein groups. In biochemical evaluations, it was determined that genistein and daidzein increased estrogen levels and decreased progesterone levels in a dose-dependent manner. Conclusion: Genistein and daidzein have a negative effect on endometrial receptivity. Therefore, individuals with a risk of infertility should pay attention to the consumption of genistein and daidzein.
کلیدواژه‌های انگلیسی مقاله Daidzein, Endometrial Receptivity, Genistein, Rat, Soy Isoflavonoids
نویسندگان مقاله | Erdem Toktay
Kafkas University, Faculty of Medicine, Department of Histology and Embryology, Kars


| Jale Selli
Alanya Alaaddin Keykubat University, Faculty of Medicine, Department of Histology and Embryology, Antalya


| Muhammed Gurbuz
Ataturk University, Faculty of Medicine, Department of Histology and Embryology, Erzurum


| Tugba Tastan
Ataturk University, Faculty of Medicine, Department of Histology and Embryology, Erzurum


| Rustem Anil Ugan
Ataturk University, Faculty of Pharmacy, Department of Pharmacology, Erzurum


| Harun Un
Agrı Ibrahim Cecen University, Faculty of Pharmacy, Department of biochemistry, Ağrı


| Zekai Halici
Ataturk University, Faculty of Medicine, Department of Pharmacology, Erzurum
نشانی اینترنتی https://ijbms.mums.ac.ir/article_16849.html
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