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Iranian Journal of Basic Medical Sciences، جلد ۲۳، شماره ۱۲، صفحات ۱۶۳۹-۱۶۴۶
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عنوان انگلیسی Gastroprotective effects of both aqueous and ethanolic extracts of Lemon verbena leaves against indomethacin-induced gastric ulcer in rats
چکیده انگلیسی مقاله Objective(s): Regarding Lemon verbena gastroprotective effects, we investigated the protective effects of Lemon verbena extracts on reducing gastric ulcer induced by indomethacin.Materials and Methods: Rats received aqueous and ethanolic extracts of Lemon verbena (50, 100, and 200 mg/kg), zileuton (100 mg/kg), montelukast (10 mg/kg), or 1% Tween 80 in presence or absence of indomethacin (100 mg/kg).Results: Indomethacin produced stomach ulcer and increased neutrophils percentage and MDA level compared with the control group (p < 0.001). Co-administration of indomethacin and zileuton, montelukast and ethanolic (200 mg/kg) (p < 0.001), aqueous extract (200 mg/kg) (p < 0.05) reduced ulcer compared with the indomethacin group (p < 0.001). Ethanolic extracts (100 and 200 mg/kg) and aqueous extract (200 mg/kg) reduced the MDA level (p < 0.001). Ethanolic (50, 100, and 200 mg/kg) and aqueous extracts (200 mg/kg) significantly decreased neutrophils percentage compared with the indomethacin group (p < 0.001).Conclusion: Aqueous and particularly ethanolic extracts of Lemon verbena have protective effects on indomethacin-induced gastric ulcers.
کلیدواژه‌های انگلیسی مقاله Indomethacin, Lemon verbena, Lippia citriodora, Gastric ulcer, NSAIDs
نویسندگان مقاله | Habibeh Mashayekhi-sardoo
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran


| Bibi Marjan Razavi
Targeted Drug Delivery Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran


| Maryam Ekhtiari
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran


| Negar Kheradmand
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran


| Mohsen Imenshahidi
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran|Pharmaceutical Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_16735.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Short Communication
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