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Iranian Journal of Basic Medical Sciences، جلد ۲۳، شماره ۱۰، صفحات ۱۲۹۳-۱۳۰۰
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عنوان انگلیسی Mesoporous silica SBA-15 decreases hyperammonemia and affects the gene expression of mitogen-activated protein kinases in the prefrontal cortex of rats with bile duct ligation
چکیده انگلیسی مقاله Objective(s): We aim to examine possible ammonia lowering effects of mesoporous silica SBA-15 in rats after the common bile duct ligation (BDL). We also evaluate the effect of SBA-15 treatments during 28 days of BDL on locomotion and rearing behavior, as well as on the gene expression of Jnk3 and p38alpha (p38α) mitogen-activated protein kinases in the prefrontal cortex (PFC).Materials and Methods: SBA-15 was prepared with the hydrothermal method from the surfactant P123 and tetraethyl orthosilicate (TEOS), and calcined at 550 ºC. Then, the product w::as char::acterized by FT-IR, XRD, SEM, and BJH-BET techniques. Male Wistar rats in sham control and a group with BDL received saline but another group with BDL received SBA-15 during 28 days of BDL. We examined all groups of rats weekly for locomotion and rearing behavior; then on day 28, we sacrificed all rats, collected the blood sample, and finally dissected the PFC from the whole brain.Results: The SBA-15 treatments had no effect on locomotion but improved rearing behavior on days 7 and 14 of BDL. Biochemical analysis indicated that the SBA-15 treatments in rats with BDL significantly decreased hyperammonemia. The results also revealed that the SBA-15 treatments in rats with BDL significantly restored the decreased Jnk3 gene expression, and increased the p38α gene expression in the PFC.Conclusion: We conclude that SBA-15 can be used as an ammonia lowering agent in hepatic encephalopathy; however, its improving effects on locomotion and neuroinflammation, as well as signaling molecules in the brain need more investigations.
کلیدواژه‌های انگلیسی مقاله Ammonia c, Jun Kinase 3 Hepatic encephalopathy Inflammations p38 MAPK SBA, 15
نویسندگان مقاله | Shamseddin Ahmadi
Department of Biological Science, Faculty of Science, University of Kurdistan, Sanandaj, Iran


| Halaleh Ghaderi
Department of Biological Science, Faculty of Science, University of Kurdistan, Sanandaj, Iran


| Nazila Saadati
Department of Biological Science, Faculty of Science, University of Kurdistan, Sanandaj, Iran


| Saadi Samadi
Department of Chemistry, Faculty of Science, University of Kurdistan, Sanandaj, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_16252.html
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