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Iranian Journal of Microbiology، جلد ۱۳، شماره ۶، صفحات ۷۵۷-۷۶۳
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عنوان انگلیسی Conjunctival polymerase chain reactions in COVID-19 patients and its correlation with clinical and paraclinical indexes
چکیده انگلیسی مقاله Background and Objectives: This study aimed to detect SARS-CoV-2 in conjunctival samples of COVID-19 patients to investigate the transmission route of COVID-19 and its correlation with laboratory indexes. Materials and Methods: In this cross-sectional study, 44 COVID-19 patients were tested for conjunctival PCR in Ayatollah Rouhani hospital of Babol, Iran, in January and February 2021. The conjunctival samples were collected using a conjunctival swab and suspended in a viral transport medium. After RNA extraction and cDNA synthesis, real-time PCR was performed to investigate the SARS-CoV-2 genome in samples. The ocular manifestations and laboratory indexes were evaluated for all patients. Results: Among 44 COVID-19 patients, 6 samples (13.63%) were positive in terms of conjunctival PCR. The mean ± SD age of conjunctival PCR-positive patients was 76.17 ± 16.61-year-old, while conjunctival PCR-negative COVID-19 patients were aged 57.54 ± 13.61-year-old (p < 0.05). D-dimer serum level is significantly higher in conjunctival PCR-positive COVID-19 patients (4001.00 ± 3043.36 µg/ml) compared to normal individuals (496.80 ± 805.92 µg/ml, p < 0.01). Conclusion: Our study showed that the conjunctiva and tear contain the SARS-CoV-2 in COVID-19 patients as a possible transmission route.
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نویسندگان مقاله | Maral Farzin
Department of Medicine, School of Medicine, Babol University of Medical Sciences, Babol, Iran


| Seyed Ahmad Rasoulinejad
Department of Ophthalmology, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran


| Mansour Babaei
Department of Rheumatology, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran


| Farzin Sadeghi
Cellular & Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran


| Mahmoud Sadeghi-Haddad-Zavareh
Department of Infectious Diseases, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran


| Alireza Firouzjahi
Department of Pathology, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran


| Behzad Heidari
Department of Rheumatology, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/3179
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