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Iranian Journal of Microbiology، جلد ۱۳، شماره ۴، صفحات ۵۰۹-۵۱۷
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عنوان انگلیسی Molecular epidemiology and phylogenetic analysis of human T-lymphotropic virus type 1 in the tax gene and it association with adult t-cell leukemia/lymphoma disorders
چکیده انگلیسی مقاله Background and Objectives: Human T-lymphotropic virus type-1 (HTLV-1) belongs to retrovirus family that causes the neurological disorder HTLV-1 adult T-cell leukemia/lymphoma (ATLL). Since 1980, seven subtypes of the virus have been recognized. HTLV-1 is prevalent and endemic in some regions, such as Africa, Japan, South America and Iran as the endemic regions of the HTLV-1 in the Middle East. To study HTLV-1 subtypes and routes of virus spread in Iran, phylogenetic and phylodynamic analyses were performed and for as much as no previous phylogenetic studies were conducted in Tehran, we do this survey. To this purpose, the Tax region of HTLV-1 was used. Materials and Methods: In this study 100 samples were collected from blood donors in Tehran. All samples were screened for anti-HTLV-I antibodies by ELISA. Then, genomic DNA was extracted from all positive samples (10 people), and for confirmation of infection, ordinary PCR was performed for both the HBZ and LTR regions. Moreover, the Tax region was amplified and purified PCR products were sequenced and analyzed, and finally, a phylogenetic tree was constructed using Mega X software. Results: Phylogenetic analysis confirmed that isolates from Iran, Japan, Brazil, and Africa are located within the extensive ‘‘transcontinental’’ subgroup A clade of HTLV-1 Cosmopolitan subtype a. The Japanese sequences are the closest to the Iranian sequences and have the most genetic similarity with them. Conclusion: Through phylogenetic and phylodynamic analyses HTLV-1 strain in Tehran were characterized in Iran. The appearance of HTLV-1 in Iran was probably happened by the ancient Silk Road which linked China to Antioch.
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نویسندگان مقاله | Samira Pourrezaei
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Shahrzad Shadabi
Department of Virology, School of Medical Sciences, Kerman University of Medical Sciences, Kerman, Iran


| Maryam Gheidishahran
Department of Medical Hematology and Blood Transfusion, School of Allied Medical Science, Iran University of Medical Sciences, Tehran, Iran


| Abbas Rahimiforoushani
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Masoume Akhbari
Department of Molecular Medicine, School of Medical Science, Karaj University of Medical Sciences, Karaj, Iran


| Mahnaz Tavakoli
Department of Medical Microbiology, School of Medical Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Mahshid Safavi
Department of Medical Microbiology, School of Medical Science, Karaj University of Medical Sciences, Iran


| Mobina Madihi
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Mehdi Norouzi
Department of Virology, Institute of Health Research, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/3051
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