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Iranian Journal of Microbiology، جلد ۱۳، شماره ۳، صفحات ۳۵۲-۳۵۹
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عنوان انگلیسی Antifungal activities of quince seed mucilage hydrogel decorated with essential oils of Nigella sativa, Citrus sinensis and Cinnamon verum
چکیده انگلیسی مقاله Background and Objectives: Candidiasis and pityriasis versicolor are opportunistic fungal infections that are caused by Candida spp. and Malassezia spp. yeasts. Conventional drugs like azole and amino derivatives are known to treat fungal skin diseases. However, drawbacks like long-term side effects and drug resistance lead to investigate on antifungal properties of phytochemicals as an alternative to available synthetic drugs. Materials and Methods: The herbal nano hydrogel was successfully synthesized from Quince Seed extract followed by ultrasonic treatment and it has been formulated using a mixture of essential oils. We evaluated the antifungal in vitro assay for a mixture of essential oils in combination with herbal nano hydrogel against Candida albicans and Malasezia furfur strains by micro dilution method. Results: The results indicated that essential oils possess antifungal activity with the MIC value of 12.5 and 6.24 mg/ml against C. albicans and M. furfur, respectively. No fungicidal effect was reported for the herbal hydrogel before nanofabrication while it shown some antifungal activity after ultrasonic treatment for 5 and 10 minutes. As anticipated; the antifungal property of essential oil mixture was appreciably improved when it combined with herbal nano hydrogel where the highest level of inhibition was observed at concentration of 3.125 mg/ml for both strains. The loss in biological activity observed when the ultrasonic treatment on herbal nano hydrogel performed for longer time. Conclusion: The proposed plant-based nano formulation shown promising in vitro antifungal activities against C. albicans and M. furfur strains and its antifungal properties were comparable with commercially available agents like clotrimazole. The new formulation expected to be safe with minimum long-term side effects. Further investigations are underway to confirm the safety and the mechanism of the action of this new herbal formulation.
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نویسندگان مقاله | Mehdi Mirzaii
Department of Microbiology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran


| Marzieh Yaeghoobi
Department of Microbiology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran


| Meysam Afzali
Department of Microbiology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran


| Neginsadat Amirkhalili
Young and Elite Research Club, Tehran North Branch, Islamic Azad University, Tehran, Iran


| Majid Mahmoodi
Department of Microbiology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran


| Esmaeil Babakhanzadeh Sajirani
Department of Horticulture Crops Research, Horticultural Sciences Research Institute, Agricultural and Natural Resources Research Center of Semnan Province, Shahrood, Iran
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/2608
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