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Iranian Journal of Microbiology، جلد ۱۳، شماره ۱، صفحات ۲۳-۳۰
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عنوان انگلیسی Clinical characteristics and molecular detection of Bordetella pertussis in hospitalized children with a clinical diagnosis of whooping cough in Peru
چکیده انگلیسی مقاله Background and Objectives: Pertussis is an infectious disease caused by the Gram-negative bacterium Bordetella pertussis. In Peru, actual public health programs indicate that vaccination against B. pertussis must be mandatory and generalized, besides all detected cases must be reported. The objective of this study was to determine the prevalence of B. pertussis among children under five years of age with a presumptive diagnosis of whopping cough in Cajamarca, a region located in northern Peru. Materials and Methods: The population of this cross-sectional study were children under 5 years old hospitalized as presumptive cases of pertussis during December 2017 to December 2018. The nasopharyngeal samples were analyzed by real-time PCR for the detection of B. pertussis. Results: B. pertussis was identified as PCR + in 42.3% of our sample (33/78). The clinical presentation that was observed most frequently includes paroxysmal coughing (97%), difficulty breathing (69.7%), cyanosis (72.7%) and post-tussive emesis (60.6%). Additionally, pneumonia was the most observed complication (33.3%). Four of the patients with PCR+ for B. pertussis presented only lymphocytosis, five only leukocytosis, two patients with decreased leukocytosis and lymphocytes and only one patient with leukopenia and relative lymphocytosis. There was a percentage of 84.8% of unvaccinated children in the PCR+ group. Finally, the mother was the most frequent symptom carrier (18.2%). Conclusion: In conclusion, in the studied population there is a high rate of PCR+ cases for B. pertussis. Laboratory values may show leukopenia or lymphopenia in patients with pertussis. It is necessary to use appropriate laboratory diagnostic tests in all infants with respiratory symptoms for B. pertussis. Since, the clinical diagnosis overestimates the diagnosis of pertussis.
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نویسندگان مقاله | Juana del Valle-Mendoza
Molecular and Cell Biology Laboratory, Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru; Department of Medicine, Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru; Molecular Biology Laboratory, Instituto de Investigación Nutricional, Lima, Peru


| Cristina del Valle-Vargas
Department of Medicine, School of Medicine, Univesidad de Barcelona, Barcelona, Spain


| Ronald Aquino-Ortega
Molecular and Cell Biology Laboratory, Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru; Molecular Biology Laboratory, Instituto de Investigación Nutricional, Lima, Peru


| Luis del Valle
Barcelona Research Center for Multiscale Science and Engineering, Departament d’Enginyeria Quıímica, EEBE, Universidad Politècnica de Catalunya (UPC), Barcelona, Spain


| Erico Cieza-Mora
Peditric Unit, Hospital Regional Docente de Cajamarca, Cajamarca, Peru


| Wilmer Silva-Caso
Molecular and Cell Biology Laboratory, Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru; Department of Medicine, Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru; Molecular Biology Laboratory, Instituto de Investigación Nutricional, Lima, Peru; Comité del Médico Joven-Consejo Nacional, Colegio Médico del Perú, Lima, Peru


| Jorge Bazán-Mayra
Molecular Biology Laboratory, Laboratorio Regional de Cajamarca, Dirección Regional de Salud de Cajamarca (DIRESA), Cajamarca, Peru


| Victor Zavaleta-Gavidia
Molecular Biology Laboratory, Laboratorio Regional de Cajamarca, Dirección Regional de Salud de Cajamarca (DIRESA), Cajamarca, Peru


| Miguel Angel Aguilar-Luis
Molecular and Cell Biology Laboratory, Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru; Department of Medicine, Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru; Molecular Biology Laboratory, Instituto de Investigación Nutricional, Lima, Peru


| Hernán Cornejo-Pacherres
Molecular Biology Laboratory, Laboratorio Regional de Cajamarca, Dirección Regional de Salud de Cajamarca (DIRESA), Cajamarca, Peru


| Johanna Martins-Luna
Molecular and Cell Biology Laboratory, Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru; Molecular Biology Laboratory, Instituto de Investigación Nutricional, Lima, Peru


| Angela Cornejo-Tapia
Molecular and Cell Biology Laboratory, Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru; Department of Medicine, Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/2581
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