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Iranian Journal of Blood and Cancer، جلد ۱۳، شماره ۴، صفحات ۱۴۰-۱۴۳
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عنوان انگلیسی TdT Negative Lymphoblastic Lymphoma: A Case Report
چکیده انگلیسی مقاله vAcute lymphoblastic leukemia/lymphomas are tumors made of the precursor B or T cells. Precursor B cell type presents as acute leukemia, and most cases of pediatric leukemia are of this type. Malignancies originated from T cells are less common and are often manifested as lymphoma in adolescents. Terminal deoxynucleotidyl tranferase (TdT) is a DNA polymerase that is present in immature pre-B and pre-T cells. TdT enzyme is a sign of cell immaturity and is used to differentiate the dominant types of lymphoblastic lymphoma from mature lymphoma/leukemia cells. TdT is expressed in 90%–95% of lymphoblastic lymphoma cells. Childhood TdT negative lymphoblastic leukemia/lymphoma is very infrequent and its prognostic significance remains challenging. It is suggested that TdT negative lymphoblastic leukemia/lymphoma shows poor response to chemotherapy and has a more disastrous course. Here, we report a case of TdT negative T-cell lymphoblastic lymphoma in a 10-year-old boy who presented with respiratory distress.
کلیدواژه‌های انگلیسی مقاله Terminal deoxynucleotidyl tranferase (TdT), Acute lymphoblastic leukemia/lymphomas, TdT negative T cell malignancy, Children
نویسندگان مقاله | Fariba Binesh
Department of Pathology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


| Alireza Jenabzadeh
Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran


| Mohammad Ali Dideban
Department of Pathology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


| Najmeh Beheshti
Department of Pathology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


| Fatemeh Khaleghi
Department of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


| Seyed Hossein Shahcheraghi
Infectious Diseases Research Center, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
نشانی اینترنتی http://ijbc.ir/browse.php?a_code=A-10-699-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pediatric Hematology & Oncology
نوع مقاله منتشر شده گزارش مورد
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