این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Blood and Cancer، جلد ۱۳، شماره ۳، صفحات ۸۵-۹۱
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Evaluation of Lipid Peroxidation, Antioxidant Status and Trace Elements in Red Blood Cell Concentrates during Storage
چکیده انگلیسی مقاله Background: Red blood cell concentrates (RBCs) undergo biochemical and structural changes during storage, commonly referred to as the RBC storage lesion (RSL) which reduces the survival of RBCs and affect transfusion efficiency. Lipid peroxidation and oxidative damage are the most important side effect of RSL. We aimed to evaluate oxidative damage and some related parameters in RBCs during storage.  Methods: In this experimental study, eight RBCs bags were randomly selected from healthy blood donors and stored at 2-6 °C for 35 days. Oxidative stress markers, trace elements and RBCs metabolism parameters including total antioxidant capacity (TAC), malondialdehyde (MDA), zinc, copper, manganese, selenium, iron, magnesium, sodium, potassium, lactate, glucose, lactate dehydrogenase (LDH) enzyme activity, pH and also RBCs hematological indexes including hemoglobin, hematocrit, MCV, MCH, MCHC and free plasma hemoglobin were evaluated during of RBCs storage.  Results: The results showed a significant increase in hemoglobin, hematocrit, calcium, phosphorus, iron, magnesium, lactate, potassium, free plasma hemoglobin, TAC and LDH activity during RBCs storage according to one way analysis of variance (P< 0.05), while a significant decrease was shown in pH, sodium and glucose concentration (P< 0.05). No significant mean changes were seen in MDA, zinc, copper, manganese and selenium concentration during RBC storage. Conclusion: It seems that RBCs at the end of the storage period have a lower quality than newly prepared ones. Therefore, we commend that RBC products rather be used before third week of storage due to post transfusion side effects in blood recipients. 
کلیدواژه‌های انگلیسی مقاله Red blood cell concentrate, Red blood cell storage lesion, Oxidative damage, Lipid peroxidation, Antioxidant status, Trace elements
نویسندگان مقاله | Sara Danehpash
Islamic Azad University, Pharmaceutical Sciences Branch (IAUPS), Tehran, Iran


| Hamid Shirkhanloo
Research Institute of Petroleum Industry (RIPI), Tehran, Iran


| Kian Azami
Islamic Azad University, pharmaceutical Sciences Branch (IAUPS), Tehran, Iran


| Mohammad Reza Deyhim
Blood Transfusion Research Center, High Institute for Research and Education for Transfusion Medicine, Tehran, Iran
نشانی اینترنتی http://ijbc.ir/browse.php?a_code=A-10-198-2&slc_lang=en&sid=1
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Methodology
نوع مقاله منتشر شده پژوهشی
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات