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Iranian Journal of Blood and Cancer، جلد ۱۳، شماره ۳، صفحات ۹۲-۹۷
عنوان فارسی
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عنوان انگلیسی Effects of Topical Vitamin E Mouthwash in Preventing Oral Mucositis in Allogenic Hematopoietic Stem Cell Transplant Patients: A Double-Blind, Placebo-Controlled Trial
چکیده انگلیسی مقاله Background: Oral mucositis is considered a frequent complication of conditioning regimen in patients undergoing hematopoietic stem cell transplantation (HSCT). Mucositis develops due to direct and indirect damage to the epithelial cells and production of reactive oxygen species (ROS). Vitamin E has shown positive effects in reducing production of ROS or improving its elimination. The aim of this study was to evaluate the effects of vitamin E mouthwash in lowering the incidence and severity of acute mucositis in patients undergoing allogenic HSCT. Methods: The current study was designed as a double bind, placebo controlled randomized clinical trial. Eighty patients were randomized in a 1 to 1 method to receive either placebo or vitamin E mouthwash. Patients in vitamin E group received 400 International Units of vitamin E in form of mouthwash twice daily and placebo group received a mouthwash with equal composition but without vitamin E, starting the day of the chemotherapy initiation and continuing it for 14 days.   Results: Vitamin E mouthwash effectively reduced the duration of oral mucositis compared to placebo (P-value 0.02). The difference between placebo and vitamin E groups in terms of mucositis severity did not reach statistical significance (P=0.35). No difference in length of hospital stay was observed (P=0.46). Conclusion: Vitamin E mouthwash could effectively reduce the duration of oral mucositis in allogenic HSCT patients. Further studies are required to show the effects of topical vitamin E in preventing the development of oral mucositis. 
کلیدواژه‌های انگلیسی مقاله Oral mucositis, Vitamin E, Prophylaxis, Topical mouthwash, Hematopoietic stem cell transplantation
نویسندگان مقاله | Mohammad Solduzian
Department of Clinical Pharmacy, Faculty of Pharmacy, Tabriz University of Medical Science, Tabriz, Iran


| Molouk Hadji Babaei
Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran Research Center for Rational Use of Drugs, Tehran University of Medical Science, Tehran, Iran


| Navid Goodarzi
Nanotechnology Research Centre, Tehran University of Medical Sciences


| Hooshyar Honarmand
Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran


| Nazanin Shabanir
Nanomedicine and Biomaterial Lab, Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran


| Zohre Labbani Motlagh
epartment of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran


| Hamidreza Taghvaye-Masoumi
Department of Clinical Pharmacy, Faculty of Pharmacy, Guilan University of Medical Science, Guilan, Iran


| Zahra Jahangard-Rafsanjani
Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran


| Hosein Kamran Zadeh
Hematology-Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.


| Kourosh Sadeghi
Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran
نشانی اینترنتی http://ijbc.ir/browse.php?a_code=A-10-685-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Adults Hematology & Oncology
نوع مقاله منتشر شده پژوهشی
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