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Iranian Journal of Blood and Cancer، جلد ۱۳، شماره ۱، صفحات ۶-۱۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Prevalence and Specificity of Red Blood Cell Alloantibodies among Patients with Solid Tumors in a Teaching Hospital in Malaysia
چکیده انگلیسی مقاله Background: Red blood cell (RBC) alloimmunization is an important complication following repeated packed RBC transfusions in patients with anemia. We aimed to determine the prevalence of RBC alloimmunization and the characteristics of the RBC antibodies among patients with solid tumors in Hospital Universiti Sains Malaysia (Hospital USM).  Methods: A cross-sectional study was performed from May 2018 to May 2019 in the Transfusion Medicine Unit of Hospital USM, on 322 adult patients with solid tumors. The blood samples were screened for the presence of RBC alloantibodies. Samples with positive antibody screening were subjected for antibody identification.  Results:  The mean age of the patients was 52 years old. Most were Malays (91%) and female (61.2%). The three most common cancers were breast (32.3%), gastrointestinal (16.8%) and head and neck (14.0%). The overall prevalence of RBC alloimmunization was 5.3%. Most alloimmunized patients had a single alloantibody (88.2%). The anti-Mia comprised the most common alloantibody (26.3%) followed by anti-E (10.5%) and anti-Lea (10.5%).  Conclusion: This study showed low prevalence of RBC alloimmunization among patients with cancers. The alloantibodies were clinically non-significant. Thus, routine antibody screening and extensive RBC phenotyping in cancer patients who need multiple transfusions is not warranted.
کلیدواژه‌های انگلیسی مقاله RBC antigens, Alloimmunization, Solid tumors, Blood transfusion, Antibody screening
نویسندگان مقاله | Che Faridah Che Wanik
1Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.


| Mohd Nazri
Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia. and Hospital USM, Health Campus, USM, 16150 Kubang Kerian, Kelantan, Malaysia.


| Noor Haslina Mohd Noor
Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia. and Hospital USM, Health Campus, USM, 16150 Kubang Kerian, Kelantan, Malaysia.


| Zefarina Zulkafli
Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia. and Hospital USM, Health Campus, USM, 16150 Kubang Kerian, Kelantan, Malaysia.


| Shafini Mohamed Yusoff
Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia. and Hospital USM, Health Campus, USM, 16150 Kubang Kerian, Kelantan, Malaysia.


| Rosnah Bahar
Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia. and Hospital USM, Health Campus, USM, 16150 Kubang Kerian, Kelantan, Malaysia.


| Marini Ramli
Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia. and Hospital USM, Health Campus, USM, 16150 Kubang Kerian, Kelantan, Malaysia.


| Salfarina Iberahim
Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia. and Hospital USM, Health Campus, USM, 16150 Kubang Kerian, Kelantan, Malaysia.


| Wan Suriana Wan Ab Rahman
Hospital USM, Health Campus, USM, 16150 Kubang Kerian, Kelantan, Malaysia. and School of Dental Sciences Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
نشانی اینترنتی http://ijbc.ir/browse.php?a_code=A-10-537-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Adults Hematology & Oncology
نوع مقاله منتشر شده پژوهشی
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