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Iranian Journal of Blood and Cancer، جلد ۱۳، شماره ۱، صفحات ۱۱-۱۶
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عنوان انگلیسی Prognostic Impact of Interleukin-10 in Patients with Chronic Lymphocytic Leukemia
چکیده انگلیسی مقاله Background: Several markers are investigated for prognostic purpose in CLL patients among which interleukin-10 (IL-10) is under more investigation. We aimed to study IL-10 level in a group of newly diagnosed patients with CLL in a single center in Alexandria, Egypt. Methods: In this study, 80 newly diagnosed patients with CLL referring to Hematology Department of the Medical Research Institute of Alexandria University, Egypt, and a control group including 40 healthy volunteers were included. ZAP-70 was determined by flowcytometry and serum IL-10 concentration was measured using IL-10 sandwich ELISA method. Results: Mean serum IL-10 levels were significantly higher among patients with CLL. IL-10 level was higher in those who were positive for ZAP-70, Binet stage C, Rai stage III-IV and patients with high scores for CLL prognostic index (≥8). It showed significant positive correlation with the percentage of ZAP-70 expression and significant negative correlation to hemoglobin and platelets count. Conclusion: Serum IL-10 in patients with CLL at presentation could be used as a prognostic marker for disease progression. Measurement of IL-10 in low resources areas where flowcytometry is not available could be recommended as a substitute investigation.
کلیدواژه‌های انگلیسی مقاله Chronic lymphocytic leukemia, Egypt, IL-10 level, ZAP-70, Binet stage, Rai stage, Prognosis, Correlation
نویسندگان مقاله | Waiel Mohmed Al-Kahiry
Department of Hematology, Faculty of Medicine and Health Sciences, University of Aden, Yemen


| Maha Abubakr Feissal Rabie
Department of Medical Laboratory Technology, Pharos University in Alexandria, Egypt


| Homam Mohamed Sharshira
Department of Hematology, Medical Research Institute, University of Alexandria, Egypt


| Amal Mostafa Ghanem
Department of Hematology, Medical Research Institute, University of Alexandria, Egypt


| Maha Mohamed El-gammal
Department of Hematology, Medical Research Institute, University of Alexandria, Egypt


| Irene Lewis Mikhael
Department of Hematology, Medical Research Institute, University of Alexandria, Egypt
دانشگاه اسکندریه

نشانی اینترنتی http://ijbc.ir/browse.php?a_code=A-10-555-1&slc_lang=en&sid=1
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Adults Hematology & Oncology
نوع مقاله منتشر شده پژوهشی
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