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Iranian Journal of Blood and Cancer، جلد ۱۲، شماره ۳، صفحات ۷۵-۷۹
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عنوان انگلیسی What We Know of the Prognostic Value of Lymphopenia in SARS-CoV-2 Infection
چکیده انگلیسی مقاله Background: Although by comparing the number of deaths to the total number of cases one may conclude that most of the infected cases are recovering, taking a look at the increasing statistics of deaths shows that SARS-CoV-2 continues to take its toll. Since lymphocytes are the main immune cells battling with rapidly evolving viruses, it comes as no surprise to assume that a decreased number of these propitious soldiers may contribute to poor prognosis of the wide range of viral infections, including COVID-19.  Methods: To provide a better prospect representing the prognostic value of lymphopenia in COVID-19, we searched the national library of medicine Medline/PubMed and performed a meta-analysis of pertinent literature representing information on the lymphocyte count in COVID-19 patients.  Results: The results of our meta-analysis revealed that the number of lymphocytes retains a specific clinical and biological significance in this infection and lymphopenia is seemingly an important hematological abnormality that contributes to mirror the evolution toward an unfavorable outcome.  Conclusion: The rapidly evolving nature of COVID-19 together with relentless disclosure of novel findings denotes a major limitation to the current study, and further investigations in the field of prognostic biomarkers will definitively pave the way to better manage patients with severe COVID-19. 
کلیدواژه‌های انگلیسی مقاله SARS-CoV-2, COVID-19, Prognosis, Lymphocyte, Lymphopenia, Meta-analysis
نویسندگان مقاله | Atieh Pourbagheri-Sigaroodi
Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Davood Bashash
Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Meysam Olfatifar
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Sina Salari
Department of Medical Oncology, Hematology and Bone Marrow Transplantation, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Hassan Abolghasemi
Pediatric Congenital Hematologic Disorders Research Center, Mofid Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
نشانی اینترنتی http://ijbc.ir/browse.php?a_code=A-10-512-2&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Infectious Diseases
نوع مقاله منتشر شده مقاله مروری
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