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Research in Pharmaceutical Sciences، جلد ۱۷، شماره ۲، صفحات ۱۵۳-۱۶۳
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عنوان انگلیسی Effect of L-carnitine on potassium dichromate-induced nephrotoxicity in rats: modulation of PI3K/AKT signaling pathway
چکیده انگلیسی مقاله Background and purpose: Kidney diseases impose significant global health challenges. Potassium dichromate (PD) is a heavy metal frequently associated with nephrotoxicity. PD prompts oxidative and inflammatory injuries in renal tissues. L-carnitine is a naturally-occurring amino acid commonly used as a supplement. Experimental approach: Forty rats were randomly allocated into 5 groups. Group 1 (normal) received only saline. Nephrotoxicity was induced in the remaining groups by PD (15 mg/kg; i.p). Group 2 served as a nephrotoxic group. Groups 3-5 received L-carnitine (25, 50, and 100 mg/kg; p.o.), respectively for 4 weeks. Findings/Results: PD administration resulted in elevated serum creatinine and blood urea nitrogen accompanied by diminished reduced glutathione and elevated malondialdehyde, tumor necrosis factor-alpha, ,and transforming growth factor-beta renal tissue contents relative to normal rats. PD also produced apoptotic histopathological injuries and down-regulated PI3K/Akt signaling pathway; signifying ongoing apoptosis. In the current work, L-carnitine use in the selected dose levels resulted in improvement of all the aforementioned serum, renal tissue, and histological parameters relative to nephrotoxic rats. L-carnitine up-regulated PI3K/Akt signaling pathway that was down-regulated post PD use. Conclusion and implications: Collectively, the study highlighted that the possible mechanisms beyond the beneficial effects of L-carnitine are mainly through its antioxidant as well as anti-inflammatory actions. L-carnitine significantly abrogated apoptosis via up-regulation of PI3K/Akt signaling pathway and signified restoration of normal renal cell proliferation and functionality.
کلیدواژه‌های انگلیسی مقاله L-carnitine,Nephrotoxicity,PI3K/Akt pathway,Potassium dichromate.
نویسندگان مقاله | Abeer A.A. Salama
1Pharmacology Department, Medical Research And Clinical Studies Institute,, National Research Centre, ID:(60014618), Dokki, Cairo, Egypt.


| Rasha E. Mostafa
2Narcotics, Ergogenics and Poisons Department, Medical Research And Clinical Studies Institute,, National Research Centre, Dokki, Cairo, ID:(60014618), Egypt.


| Rania Elgohary


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/2115
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