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Research in Pharmaceutical Sciences، جلد ۱۶، شماره ۵، صفحات ۴۴۷-۴۵۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Chimeric antigen receptor‑T cells immunotherapy for targeting breast cancer
چکیده انگلیسی مقاله Redirected chimeric antigen receptor (CAR) T-cells can recognize and eradicate cancer cells in a major histocompatibility complex independent manner. Genetic engineering of T cells through CAR expression has yielded great results in the treatment of hematological malignancies compared with solid tumors. There has been a constant effort to enhance the effectiveness of these living drugs, due to their limited success in targeting solid tumors. Poor T cell trafficking, tumor-specific antigen selection, and the immunosuppressive tumor microenvironment are considered as the main barriers in targeting solid tumors by CAR T-cells. Here, we reviewed the current state of CAR T-cell therapy in breast cancer, as the second cancer-related death in women worldwide, as well as some strategies adopted to keep the main limitations of CAR T-cells under control. Also, we summarized various approaches that have been developed to enhance the therapeutic outcomes of this treatment in solid tumors targeting.
کلیدواژه‌های انگلیسی مقاله Adoptive immunotherapy,Breast neoplasms,Cell-based therapy,Chimeric antigen receptor.
نویسندگان مقاله | Ilnaz Rahimmanesh
2Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.


| Hossein Khanahmad


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/2080
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Mini Review Article
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