این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Research in Pharmaceutical Sciences، جلد ۱۶، شماره ۵، صفحات ۵۱۶-۵۲۷
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effect of ethanolic extract of Stachys pilifera Benth on subacute experimental models of inflammation and some underlying mechanisms
چکیده انگلیسی مقاله Background and purpose: This study was designed to evaluate the anti-inflammatory activities of S. pilifera (HESP) in two sub-acute models of inflammation and clarified some possible mechanisms. Experimental approach: Colorimetric methods were used to determine total phenol and flavonoid contents. Carrageenan or formalin-induced rat paw edema (seven days) and multiple application TPA-induced ear edema in mice (9 days) were used. The concentration of IL-1 and TNF-α were measured in the inflamed paw, as well as MDA levels in the serum and liver. Histopathological studies and in vitro anti-inflammatory effects of the extract were also studied using heat-or hypotonicity-induced hemolysis in RBC humans. Findings/Results: Total phenol and flavonoid contents of HESP were 101.35 ± 2.96 mg GAE/g extract and 660.79 ± 10.06 mg RE g extract, respectively. Oral (100 and 200 mg/kg) and topical application (5 mg/ear) of HESP significantly inhibited formalin-induced paw edema and multiple TPA-induced ear edema. The extract also significantly decreased the serum and liver levels of MDA in the carrageenan and formalin tests. The elevated levels of TNF-α and IL-1β in the carrageenan-injected paw were not affected by HESP. The extract (50-800 µg/mL) inhibited heat-or hypotonicity-induced hemolysis. Histopathological examination of the inflamed tissues revealed that HESP inhibited congestion and leukocyte infiltration. Conclusion and implications: The findings confirmed the potent anti-inflammatory effects of S. pilifera in two sub-acute inflammation models and suggested that these properties were not related to IL-1 and TNF-α, but could be attributed to inhibition of lipid peroxidation, membrane stabilization, and inhibition of leukocyte penetration.
کلیدواژه‌های انگلیسی مقاله Anti-inflammatory,IL-1beta,Stachys pilifera Benth,TNF-alpha,TPA.
نویسندگان مقاله | Vahid Zarezade
2Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, I.R. Iran.


| Heibatollah Sadeghi
2Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, I.R. Iran.


| Esmaeel Panahi Kokhdan
2Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, I.R. Iran.


| Jafar Nikbakht
3Department of Internal Medicine, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, I.R. Iran.


| Mehdi Molavi
4Department of Biochemistry and Clinical Laboratories, Tabriz University of Medical Sciences, Tabriz, I.R. Iran.


| Mostafa Mostafazadeh
2Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, I.R. Iran.


| Sayed Aghil Abedi
2Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, I.R. Iran.


| Hossein Sadeghi


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/2087
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات