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Research in Pharmaceutical Sciences، جلد ۱۶، شماره ۳، صفحات ۲۸۶-۲۹۳
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عنوان انگلیسی Effects of valsartan on morphine tolerance and dependence in rats
چکیده انگلیسی مقاله Background and purpose: Opiates are traditionally used for the treatment of pain. Chronic consumption of opiates such as morphine (MOR) induces tolerance and dependence. This study aimed to investigate the effects of valsartan (VAL), as an angiotensin II receptor blocker, on the induction and expression of MOR analgesic tolerance and physical dependence in rats. Experimental approach: MOR 10 mg/kg was injected s.c. twice a day for 7 days to induce tolerance and dependence. For evaluating the effect of VAL on the induction of MOR analgesic tolerance and physical dependence, 20 mg/kg VAL was administered orally (once a day) during the 7 days of the examination period. The tail-flick test was performed every day. On day 7, 5 mg/kg naloxone () was injected s.c. into the morphine-dependent rats and the rats were monitored for 30 min for the frequency of withdrawal signs such as jumping, diarrhea, defecation, head tremor, rearing, scratching, sniffing, teeth chattering, and wet-dog shake. For evaluating the effect of VAL on the expression of MOR-analgesic tolerance and physical dependence, 45 min before the last MOR injection, VAL was administered only on day 7. The tail-flick test was performed and naloxone was injected into the addicted rats and they were monitored for 30 min for the frequency of withdrawal signs such as jumping, diarrhea, defecation, head tremor, rearing, scratching, sniffing, teeth chattering, and wet-dog shake. Findings/Results: Our results revealed that the co-administration of VAL with MOR for 7 consecutive days reduced the induction of MOR tolerance. Moreover, VAL administration for 7 days along with MOR reduced the frequency of diarrhea and defecation in naloxone-injected animals. Conclusion and implications: According to the results presented in this study, chronic administration of VAL prevented the induction of MOR-analgesic tolerance and dependence in rats.
کلیدواژه‌های انگلیسی مقاله Keywords, Morphine,Physical dependence,Rat,Tolerance,Valsartan.
نویسندگان مقاله | Ayat Kaeidi
3Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, I.R. Iran.


| Morteza Amirteimoury
3Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, I.R. Iran.


| Mohammad-Saleh Zare
3Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, I.R. Iran.


| Amirhossein Nazari
1Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, I.R. Iran.


| Elham Hakimizadeh
1Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, I.R. Iran. 2Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, I.R. Iran.


| Jalal Hassanshahi
4Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, I.R. Iran.


| Iman Fatemi


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/2065
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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