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Research in Pharmaceutical Sciences، جلد ۱۵، شماره ۶، صفحات ۵۶۳-۵۷۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Synthesis and cytotoxicity evaluation of novel cyclic/non-cyclic N-aryl enamino amides against human cancer cell lines
چکیده انگلیسی مقاله Background and purpose: Considering the undesirable consequences of prevalent cancer diseases, design and development of potent and selective anticancer chemotherapeutics is a major concern. Several studies have unraveled the potential of dihydropyrimidinone (DHPM) scaffold toward generating anticancer agents. Experimental approach: In the present work, a series of new dihydropyrimidinethiones (DHPMTs) along with a few acyclic enamino amides were synthesized and evaluated for their cytotoxic activity against human gastric (AGS), liver (Hep-G2), and breast (MCF-7) cancer cell lines. Findings/Results: Among the assessed compounds, one of the DHPMT derivatives (compound 5 : 4-(3-fluorophenyl)-6-methyl- N -phenyl-2-thioxo-1,2,3,4-ttrahydropyrimidine-5-carboxamide) exhibited superior cytotoxicity in all of the target cell lines (AGS, IC 50 9.9 µM; MCF-7, IC 50 15.2 µM; and Hep-G2, IC 50 40.5 µM). Cytotoxicity assessments showed that non-cyclic enamino amides exhibited weaker activities when compared to cyclic analogues (DHPMs). Conclusion and implications: DHPMTs were better cytotoxic agents than non-cyclic enamino amides. Structure activity relationship studies guided us toward the design of DHPMT derivatives with OH and NH groups particularly on meta position of 4-phenyl ring and hydrophobic bulky substituents on carboxamide side chain within the structure. Possible interaction with the hydrophobic site(s) of the cellular target was supposed. The results of this study emphasized the potential role of DHPMTs and their optimized derivatives as privileged medicinal scaffolds to inhibit the growth of gastric, breast, and liver cancer cells.
کلیدواژه‌های انگلیسی مقاله Keywords, Cancer,Cytotoxicity,Dihydropyrimidinethione,Enamino amide,MTT.
نویسندگان مقاله | Shahab Bohlooli
2Department of Medicinal Chemistry, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, I.R. Iran.


| Negin Nejatkhah
2Department of Medicinal Chemistry, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, I.R. Iran.


| Saghi Sepehri
3Student Research Committee, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, I.R. Iran


| Donya Doostkamel
2Department of Medicinal Chemistry, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, I.R. Iran.


| Nima Razzaghi-Asl


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/2033
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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