این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Toxicology، جلد ۱۵، شماره ۳، صفحات ۱۶۵-۱۷۴
عنوان فارسی سطوح تغییر یافته هیستومورفومتری و ضد اکسیداتیو که به دنبال داروی بیسفنول-A در داخل بدن دنبال می شود
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Altered Testicular Histomorphometric and Antioxidant Levels Following In vivo Bisphenol-A Administration
چکیده انگلیسی مقاله Background: Bisphenol-A (BPA) is a pervasive environmental toxin that is used in the production processes of many consumables and equipment that are in daily application. The aim of this study was to determine the effects of BPA on the structural and functional integrity of the reproductive system in male Wistar rats and its interaction with melatonin. Methods: Adult female rats in pro-estrus phases were mated with adult male rats and the conception determined. The male pups were divided into two groups of A and B. These groups were further subdivided into six subgroups each. They were administered varying low doses of BPA (25 or 50mg/kg) and melatonin (10mg/kg) at neonatal and adolescent ages. The testes, epididymis and blood samples were collected for histological, semen and biochemical investigations, respectively. Results: The results show that BPA caused histological alterations, reduced quality and quantity of sperm cells, and induced oxidative stress at birth and adolescence. Conclusion: Bisphenol A exposure, even at low dose, is toxic to the male reproductive system, and melatonin administration did not significantly improve the alterations caused by the BPA.  
کلیدواژه‌های انگلیسی مقاله Adolescence, Bisphenol A, Histology, Melatonin, Neonate
نویسندگان مقاله Kadir | Eniola Risikat Kadir
Department of Anatomy, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, Nigeria.
university of ilorin,ilorin Nigeria

Ojulari | Lekan Sheriff Ojulari
Department of Physiology, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, Nigeria.
university of ilorin,ilorin Nigeria

Gegele | Taiye Abdullah Gegele
Department of Anatomy, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, Nigeria.
university of ilorin,ilorin Nigeria

Lawal | Ismail Adetayo Lawal
Department of Anatomy, Faculty of Health Sciences, Al-Hikmah University, Ilorin, Nigeria.
al-hikmah university ilorin,Nigeria

lukman | Lukman Sulu-Gambari
Department of Anatomy, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, Nigeria.
university of ilorin,ilorin Nigeria

Sulaimon | Fatimo Ajoke Sulaimon
Department of Anatomy, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, Nigeria.
university of ilorin,ilorin Nigeria

Omotoso | Gabriel Olaiya Omotoso
Department of Anatomy, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, Nigeria.
university of ilorin,ilorin Nigeria

نشانی اینترنتی http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-796-1&slc_lang=en&sid=1
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده عمومی
نوع مقاله منتشر شده پژوهشی
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات