این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Toxicology، جلد ۱۵، شماره ۳، صفحات ۲۰۵-۲۱۴
عنوان فارسی Effect of Nano-eugenol and Aerobic Exercise Against the Streptozotocin Toxicity and Inflammatory Mediators P۳۸-MAPK, NPY, and A-Rα۲A in the Dorsal root Ganglia of Diabetic Rats
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effect of Nano-eugenol and Aerobic Exercise Against the Streptozotocin Toxicity and Inflammatory Mediators P38-MAPK, NPY, and A-Rα2A in the Dorsal Root Ganglia of Diabetic Rats
چکیده انگلیسی مقاله Background: The aim of this study was to investigate the effects of nano-eugenol combined with aerobic exercise against the streptozotocin toxicity and inflammatory mediators P38-MAPK, NPY and A-Rα2A in the dorsal root ganglia of diabetic rats. Methods: Twenty-five, 8-week-old Wistar male rats were divided into 5 groups: 1) normal control group (normal model); 2) diabetic control group (diabetic model); 3), diabetic + exercise group (diabetic+exercise model); 4) diabetic group + nano-eugenol (diabetic+nano model); and 5) diabetic + exercise + nano-eugenol (diabetic+exercise+nano model). Diabetes was induced in the experimental groups 2 through 5 by the intraperitoneal injection of streptozotocin at 4mg/100 grams of the rats' body weight. The nano-eugenol supplement was also gavaged into the supplement groups 4 and 5 only. Groups 3 and 5 exercised progressively at a speed of 8 to 20 meter/min for 5 to 30 min, five days a week over the 8-week study duration.  Results: The diabetic rats that exercised and were treated with the nano-eugenol, showed a significant decrease in P38-MAPK gene expression compared to the normal model group (P=0.001). The study of the therapeutic modalities also showed that only the diabetic + exercise + nano-eugenol group showed a significant increase in NPY and A-Rα2A genes compared to the normal model (P=0.001). Conclusion: Based on the results, the use of nano-eugenol supplementation combined with aerobic exercise is likely to be effective in controlling the neurological damages due to diabetes by negatively regulating the P38-MAPK gene while positively regulating the NPY and A-Rα2A genes in the DRG region.  
کلیدواژه‌های انگلیسی مقاله Aerobic exercise, Adrenoreceptor α2A, Diabetic neuropathies, Neuropeptide Y, P38 Mitogen-Activated Protein Kinases
نویسندگان مقاله | Abbas Shareghi Boroujeni
Department of Sports Physiology, School of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.


| Khosro Jalali Dehkordi
Department of Sports Physiology, School of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.


| Gholamreza Sharifi
Department of Sports Physiology, School of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.


| Farzaneh Taghian
Department of Sports Physiology, School of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.


| Zohreh Mazaheri
Histology Laboratory, Baftogen Pasargad Institute, Tehran, Iran.
نشانی اینترنتی http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-822-1&slc_lang=en&sid=1
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده تخصصی
نوع مقاله منتشر شده پژوهشی
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات