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Iranian Journal of Toxicology، جلد ۱۴، شماره ۴، صفحات ۱۹۳-۲۰۰
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عنوان انگلیسی Prevention of Lung Complications following Paraquat Poisoning by Silymarin, N-acetyl Cysteine and Hydrocortisone: An Experimental Study
چکیده انگلیسی مقاله Background: Paraquat poisoning results in multi-organ failure, primarily pulmonary fibrosis, acute renal failure, and hepatic impairment. The present study was designed to evaluate three treatment regimens, such as N-Acetyl cysteine (NAC), silymarin and hydrocortisone in the prevention of lung fibrosis after ingestion of toxic doses of paraquat in rats.  Methods: Male Sprague-Dawley rats (N=20) were randomly divided into four groups of five each. The drugs and paraquat were given to the rats orally. All rat groups received one oral dose of paraquat (10 mg/kg) once daily for 1 week. The first group received a daily oral dose of silymarin (600 mg/kg) for 2 weeks. The second group received a daily oral dose of NAC (500 mg/kg) for 2 weeks. The third group was given daily oral doses of NAC (500 mg/kg) and hydrocortisone (50 mg/kg) for 2 weeks. The fourth group (controls) received no drugs other than paraquat. The experiment continued for 4 weeks. After the experiment, autopsy was performed on all rats and the lungs were examined histopathologically. Results: The results of histopathology examinations for peribronchial inflammation in the groups were shown that NAC plus hydrocortisone and silymarin had notable effects in the prevention of lung inflammation. Septal widening in the lungs was also observed in group three less than that in the other groups. Conclusion: Based on the results, silymarin, NAC and hydrocortisone may be used as a palliative treatment in paraquat poisoning specifically aimed at preventing the acute and chronic lung injuries as the worst complication of the poisoning.   
کلیدواژه‌های انگلیسی مقاله Paraquat, Lung fibrosis, N-acetyl cysteine, Hydrocortisone, Silymarin
نویسندگان مقاله | Mohammad Jamalian
Clinical Toxicologist & Assistant Professor, Department of Forensic Medicine, School of Medicine, Arak University of Medical Sciences, Arak, Iran.


| Hassan Solhi
Clinical Toxicologist & Professor, Department of Forensic Medicine, School of Medicine, Arak University of Medical Sciences, Arak, Iran.


| Parisa Ghasemi
Medical Practitioner, Department of Pathology, School of Medicine, Arak University of Medical Sciences. Arak, Iran.


علی رهبری | Ali Rahbari
Pathologist & Assistant Professor, Department of Forensic Medicine, School of Medicine, Arak University of Medical Sciences. Arak, Iran.
دانشگاه علوم پزشکی اراک

امیر محمد کاظمی فر | Amir Mohammad Kazemifar
Clinical Toxicologist & Associate Professor, Metabolic Diseases Research Center, Qazvin University of Medical Sciences. Qazvin, Iran.
دانشگاه علوم پزشکی قزوین

نشانی اینترنتی http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-710-1&slc_lang=en&sid=1
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