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Iranian Journal of Toxicology، جلد ۱۴، شماره ۴، صفحات ۲۵۳-۲۶۲
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عنوان انگلیسی Determination of Amphetamine and Methamphetamine by Dispersive Liquid Phase Micro-extraction: A Novel Experimental Approach
چکیده انگلیسی مقاله Background: A syringe to syringe dispersive liquid phase micro-extraction-floating organic drop was applied and used for the simultaneous extraction and pre-concentration of trace amounts of amphetamine (AMP) and methamphetamine (MAMP) in urine samples. The extracted analytes were determined by high performance liquid chromatography along with diode array detection. Methods: In this study, n-hexane was selected as the extraction solvent without the need to use dispersive solvent. The analytical parameters affecting the micro-extraction efficiency, including pH of sample solution, extraction solvent volume, the cycles of extraction and time of centrifugation were investigated and optimized by screening and optimization experimental design methods.  Results: Underoptimal conditions, the calibration curve had a linear range of 2-100 μg/L with the determination coefficient of R2=99.8 and R2=99.6 for AMP and MAMP, respectively. The limit of detection was 2 μg/L for AMP and MAMP, and the enrichment factor was 75 and 68 for AMP and MAMP, respectively.  Conclusion: This method is very simple, rapid and has been successfully used for pre-concentration and measurement of the analytes in urine samples, which is important to forensic studies.  
کلیدواژه‌های انگلیسی مقاله Dispersive liquid-phase micro-extraction, Amphetamine, Methamphetamine, Experimental design, Forensic medicine
نویسندگان مقاله | Daruish Badakhshan
Department of Chemistry, Faculty of Science, Arak Branch, Islamic Azad University, Arak, Iran.


| Majid Ramezani
Department of Chemistry, Faculty of Science, Arak Branch, Islamic Azad University, Arak, Iran.
نشانی اینترنتی http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-693-2&slc_lang=en&sid=1
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