این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Medical Physics، جلد ۱۸، شماره ۵، صفحات ۳۶۱-۳۶۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی An In-Vitro Study on Photochemical Internalization of Methylene Blue with Gold Nanoparticles Coated By Thio-Glucose
چکیده انگلیسی مقاله Introduction: Photochemical internalization is a novel PDT-based technology for the intracellular delivery of hydrophilic macromolecular therapeutic agents and other drugs limited in penetration into cellular membranes with intracellular targets. In this regard, one of the approaches is to use nanoparticles along with photosensitizing agents. In this study, the presence of thioglucose-coated gold nanoparticles in the efficiency of the photodynamic effect of methylene blue (MB) caused by the photochemical internalization phenomenon was investigated. Material and Methods: First, Glu-GNPs was synthesized, and then the toxicity of Glu-GNPs and MB were determined to achieve their optimal concentrations. Afterward, the photodynamic effects of Glu-GNPs combined with MB by Luma-Care source light were evaluated at different doses using MTT assay and colony assay (12 days after treatment). Results: According to the MTT assay, the photodynamic effect in the Glu-GNPs group revealed no significant efficacy, whereas the colony-formation capability in all groups with an optical dose of 15.6 J / cm2 decreased, compared to the similar group without light exposure (P < 0.05). Conclusion: The photodynamic efficiency of MB with the Glu-GNPs group was reduced at 15.6 J/cm2, compared to the free MB group. The decreased efficiency can have various reasons such as the photochemical bleaching of the free MB because of ROS and 1O2 produced by the plasmonic photodynamic phenomenon of Glu-GNPs or changing the optophysical properties of surface plasmon resonance of final product (MB+ Glu-GNPs) due to the possible electrostatic bonding of the drug with the nanoparticles.
کلیدواژه‌های انگلیسی مقاله Breast Cancer, Photodynamic Therapy (PDT), Gold Nanoparticles (GNPs) Methylene Blue (MB)
نویسندگان مقاله | Maryam Shabanzadeh
Department of Medical Radiation, Faculty of Engineering, Islamic Azad University, Science and Research Branch, Tehran, Iran.


| Alireza Shirazi
Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.


| Armin Imanparast
Medical Physics Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Department of Medical Physics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| zahra mohammadi
Medical Physics Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Department of Medical Physics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Ameneh Sazgarnia
Medical Physics Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Department of Medical Physics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی https://ijmp.mums.ac.ir/article_16846.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Paper
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات