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Iranian Journal of Medical Physics، جلد ۱۷، شماره ۵، صفحات ۳۱۶-۳۲۱
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Transfer of Radio-Adaptation via Serum: A Preliminary Report
چکیده انگلیسی مقاله Introduction: Adaptive response is one of the important concepts in radiobiology. The present report aimed to transfer the radio-adaptation via serum. Material and Methods: In total, 50 male adult Wistar rats were randomly divided into 6 groups, including control, serum control, low-dose (100cGy), low-dose/lethal, serum/lethal, and lethal (8Gy). Exposure was carried out by a linear accelerator (Elekta Synergy® Platform) with a 40×40cm field size. The animals were monitored in terms of the endpoints of the survival rate, and at the first stage, the rats were exposed to the low doses of radiation. Subsequently, the serum was injected intraperitoneally under sterile conditions 6 h after low-dose exposure. The Kaplan Meier Survival Curve was used to evaluate the survival rate (p < 0.05). Results: There was a significant difference among different groups regarding the survival rates. Moreover, a statistically significant difference was observed between low-dose/lethal and low-dose/serum, low-dose/lethal and lethal, and low-dose/serum and lethal (P=0.001). Similarly, there was a statistically significant difference between the control and experimental groups regarding the survival rates (P=0.001). Conclusion: To the best of our knowledge, this method can lead to immunological responses or unknown mechanisms that result in the increased survival adaptive response to subsequent high-dose radiation.
کلیدواژه‌های انگلیسی مقاله Adaptive response, Radiation Effects, Serum, Survival rate
نویسندگان مقاله | Ehsan Khodamoradi
Department of Radiology and Nuclear Medicine, Faculty of Paramedical Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Rasool Azmoonfar
Department of Radiology, Faculty of Paramedical Sciences, Hamadan University of Medical Sciences, Hamadan, Iran


| Mohammad Mohammadi
Department of Radiology and Nuclear Medicine, Faculty of Paramedical Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Amir Kiani
Associate Professor, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Abbas Haghparast
Associate Professor of Medical Physics, Department of Medical Physics, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Nasrin Sharafi
Department of Radiology and Nuclear Medicine, Faculty of Paramedical Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Loghman Diojan
Department of Radiology and Nuclear Medicine, Faculty of Paramedical Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran
نشانی اینترنتی https://ijmp.mums.ac.ir/article_14055.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Paper
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