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Basic and Clinical Cancer Research، جلد ۱۳، شماره ۲، صفحات ۹۲-۱۰۴
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عنوان انگلیسی Application of molecular biology in cancer therapy
چکیده انگلیسی مقاله Cancer is a genetic illness that develops for a variety of reasons, including the activation of onco-genes, the failure of tumor suppressor genes, or mutagenesis induced by environmental stimuli. This article was produced using data from the journals PubMed, Nature, Science Direct, Springer, and Elsevier. Oncogenes are altered forms of normal proto-oncogenic genes that are important for cell proliferation, development, and regulation. The transformation of a gene to an oncogene is caused by translocation, chromosomal translocation, or gene mutation due to addition, deletion, duplication, or viral infection. To limit malignant cell development, these oncogens are targeted by medications or the RNAi system. Various molecular biology methods for cancer detection and treatment have been developed, including retroviral therapy, oncogene silencing, and alterations in tumor suppressor genes. Among all the techniques used, RNAi, zinc finger nucleases, and CRISPR have a greater chance of reaching a cancer-free planet.
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نویسندگان مقاله | Arash Abdolmaleki
1 Department of Engineering Sciences, Faculty of Advanced Technologies, University of Mohaghegh Ardabili, Namin, Iran. 2 Bio Science and Biotechnology Research center (BBRC), Sabalan University of Advanced Technologies (SUAT), Namin, Iran.


| Aida Karimian
Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran.


| Asadollah Asadi
Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran.


| Hussein A. Ghanimi
College of Nursing, University of Al-Ameed, Karbala, PO Box 198, Iraq.


| Muhammad Akram
Department of Eastern Medicine, Government College University Faisalabad-Pakistan.
نشانی اینترنتی https://bccr.tums.ac.ir/index.php/bccrj/article/view/401
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