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Basic and Clinical Cancer Research، جلد ۱۲، شماره ۲، صفحات ۹۱-۹۷
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عنوان انگلیسی Major Risk Factors for Cervical Cancer in Northeast of Iran: Evidence from a Case-Control Study
چکیده انگلیسی مقاله Background: Cervical cancer is known to be a preventable cancer in which various risk factors play role in increasing the risk of the disease. In this study, we have assessed different risk factors involved in invasive cervical cancer in Northeast of Iran. Methods: In a case control study, 100 patients with advanced cervical cancer were compared to 100 healthy, normal women. In addition, 100 cases of prisoner women who had a high risk profile for cervical cancer were also investigated. Cervical risk factors for these groups were documented using a questionnaire and available medical notes. Univariate analysis was done for each risk factor followed by a multivariate regression analysis to evaluate the most powerful risk factors after adjustment. Result: Age of first intercourse ≤16 (P< 0.001)[OR= 4.18, 95% CI (2.32-7.54)], sexually transmitted diseases (STD) (P< 0.001) [OR=8.59,95% CI (4.25-17.37)], passive smoking (P< 0.01) [OR= 2.35, 95% CI (1.17-4.72)], smoking (P< 0.01) [OR=10.33, 95% CI (2.32-46.17)], age of first pregnancy ≤17 years (P< 0.001) [OR= 3.37, 95% CI (1.79-6.33)] were strongly related to the occurrence of cervical cancer. However, STD remained statistically significant (P< 0.01) after adjustment. 
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نویسندگان مقاله | Fatemeh Homaei Shandiz
Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.


| Alireza Pasdar
Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


| Fahimeh Afzaljavan
Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


| Zohre Takalluo
Department of Obstetrics and Gynecology, School of Medicine, Ghaem Hospital, Mashhad University of Medical Sciences.


| Malihe Hasanzadeh Mofrad
Department of Obstetrics and Gynecology, School of Medicine, Ghaem Hospital, Mashhad University of Medical Sciences.
نشانی اینترنتی https://bccr.tums.ac.ir/index.php/bccrj/article/view/355
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