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Basic and Clinical Cancer Research، جلد ۱۲، شماره ۱، صفحات ۴۲-۵۳
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عنوان انگلیسی Cryopreservation Options to Preserve Fertility in Female Cancer Patients: Available Clinical Practice and Investigational Strategies from the Oncology Guidelines Point of View
چکیده انگلیسی مقاله   In recent years, advances in cancer treatment have improved the survival rate of cancer patients significantly. However, destructive damage to ovaries due to the therapies or cancer itself can cause different degrees of infertility in women of reproductive age that can affect their quality of life seriously. In this study, fertility cryopreservation options for female cancer patients in oncology guidelines were reviewed. Cryopreservation methods have a long history in reproductive biology and oncology. However, embryo and oocyte cryopreservation were the eligible restoration strategies in clinical oncology practice. Ovarian tissue cryopreservation (OTC) is the latest option recommended for fertility preservation in pre-pubertal and adult patients who cannot delay their treatment or in whom taking IVF hormones may have adverse effects on their cancer. Reports show that frozen-thawed ovarian tissue transplantation has led to more than 130 live births so far in patients, most of whom were cancer patients. Although OTC is indeed generally recognized as an investigational method, it is recommended in some important guidelines, such as ASCO 2018. Therefore, based on many clinical pieces of evidence, it is predicted that the investigational label will soon be removed, and OTC might be considered as one of the main fertility preservation options for female cancer patients in clinical oncology practice.
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نویسندگان مقاله | Leila Mirzaeian
Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran


| Haniyeh Rafipour
School of medicine, Tehran University of Medical Science, Tehran, Iran


| Saadeh Hashemi
Vali-e-Asr Reproductive Research Health Center, Tehran University of Medical Sciences, Tehran, Iran.


| Sara Zabihzadeh
Vali-e-Asr Reproductive Research Health Center, Tehran University of Medical Sciences, Tehran, Iran.


| Saeid Amanpour
Cancer Biology Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://bccr.tums.ac.ir/index.php/bccrj/article/view/337
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