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Basic and Clinical Cancer Research، جلد ۱۲، شماره ۱، صفحات ۳۴-۴۱
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عنوان انگلیسی Effect of Quercetin and Intermittent and Continuous Exercise on Catalase, Superoxide dismutase, and Malondialdehyde in the Heart of Rats with Colon Cancer
چکیده انگلیسی مقاله Background: Colorectal cancer is the fourth leading cause of death globally, and the second most common cancer in Europe. About 8% of all cancer-related deaths occur due to colorectal cancer, and the highest prevalence has been reported in Asia and Eastern Europe. Methods: In this experimental study, 80 rats were divided into two groups of cases (n=70) and controls (n=10). Colorectal cancer was induced weekly in rats by subcutaneous injection of 15 mg/kg Azoxymethane. The rats were then divided into 7 experimental subgroups of patients, saline, quercetin, intermittent exercise, continuous exercise, quercetin plus intermittent, and quercetin plus continuous exercise. Oxidative stress biomarkers, including superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) were measured in the rats' heart tissue by the ELISA method. Data were analyzed using ANOVA by SPSS software. Results: Oxidative stress in heart cells increased due to colorectal cancer. Quercetin alone or in combination with exercise significantly increased mean levels of CAT and SOD in the heart tissue of rats compared with patient and saline groups (P< 0.0001). In contrast, the MDA level was significantly decreased (P< 0.05). Conclusion: Colorectal cancer increased the oxidative stress in cardiac cells. Quercetin alone improved oxidative stress in cardiac tissue, and its combination with exercise was more effective.
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نویسندگان مقاله | Behrooz Talaei
Student Research Committee, School of Public Health, Kerman University of Medical Science, Kerman, Iran. AND Department of Nutrition, School of Public Health, Kerman University of Medical Science, Kerman, Iran.


| Mohammad Panji
Department of Cell and Molecular Biology, Faculty of Biological Science, Kharazmi University, Tehran, Iran.


| Fatemeh Nazari Robati
Mph Candidate, Social Diameters of Health Research Center, Kerman Urban Health Center, Shafa Street, Kerman, Iran.


| Sajjad Tezerji
Student Research Committee, Kerman University of Medical Science, Kerman, Iran.
نشانی اینترنتی https://bccr.tums.ac.ir/index.php/bccrj/article/view/360
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