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Addiction and Health، جلد ۱۲، شماره ۴، صفحات ۲۵۹-۲۶۸
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عنوان انگلیسی Effect of Magnesium Sulfate Added to Tincture of Opium and Buprenorphine on Pain and Quality of Life in Women with Dysmenorrhea: A Prospective, Randomized, Double-blind, Placebo-controlled Trial
چکیده انگلیسی مقاله Background: Adding magnesium sulfate (MgSO4) to opioid receptor agonists increases the opioid analgesiceffects via blocking this receptor. The current study aimed to evaluate the effectiveness of adding MgSO4 totincture of opium (TOP) and buprenorphine (BUP) on pain and quality of life (QOL).Methods: In prospective, randomized, double-blind, placebo-controlled clinical trial, one hundred andsixty-three women with secondary dysmenorrhea caused by endometriosis were selected using a respondentdriven sampling (RDS) and assigned into six groups using block randomization. Patients received 50 mg/kgMgSO4 in 100 ml saline by micro set in six monthly menstrual periods and completed the visual analoguescale (VAS) and QOL Questionnaire (QOLQ). Data were analyzed by repeated measures analysis of variance(ANOVA) and hierarchical regression.Findings: The primary outcomes showed that pain scores in magnesium (MAG) + opium tincture (OT)[F = 5.7(1,162), P = 0.004] and MAG+ BUP [F = 4.5(1,162), P = 0.006] groups showed a significant decreasecompared with control group. Also, QOL scores in MAG + OT [F = 4.8(1,162), P = 0.005] and MAG + BUP[F = 5.9(1,162), P = 0.003] showed a significant increase. However, there was no significant differencebetween the two groups (P = 0.140) and the changes did not persist until follow-up (P = 0.810). Secondaryoutcomes indicated that the low scores of the two components of QOL including physical and psychologicalcomponents were predictors of pain (P = 0.011, Beta > 3.09).Conclusion: Simultaneous use of MAG with opioids is associated with pain reduction and the improvement ofQOL. However, this hypothesis requires careful handling in a randomized controlled trial
کلیدواژه‌های انگلیسی مقاله Dysmenorrhea, Endometriosis, Pain, magnesium sulfate, Buprenorphine
نویسندگان مقاله Bijan Pirnia |
Department of Psychology, School of Humanities, University of Science and Culture AND Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Raheleh Masoudi |
Department of Midwifery, School of Medicine, Qom Branch, Islamic Azad University, Qom, Iran

Kambiz Pirnia |
Bijan Center for Substance Abuse Treatment, Tehran, Iran

Mina Jalali |
Department of Psychology, Kish International Branch, Islamic Azad University, Kish, Iran

Mohammad Reza Eslami |
Department of Health Psychology, North Tehran Branch, Islamic Azad University, Tehran, Iran

Parastoo Malekanmehr |
Department of Psychology, School of Psychology, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran

Fariborz Pirnia |
Department of Food Science and Technology, School of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Ladan Ajori |
Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

نشانی اینترنتی http://ahj.kmu.ac.ir/article_91539_d2d4504f2692822627ea6e4a80386d87.pdf
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