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Medical Laboratory Journal، جلد ۱۶، شماره ۲، صفحات ۳۴-۴۰
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عنوان انگلیسی Vascular Senescence and Resistance Exercise Training: Focus on Circulating Endothelial Cell-Derived MicroRNA-92a and Endothelin-1
چکیده انگلیسی مقاله Background and objectives: Vascular senescence refers to specific aging-associated changes in the endothelial cells. The purpose of this study was to investigate effects of 12 weeks of resistance training with elastic bands on circulating endothelial cell-derived microRNA-92a and endothelin-1 (ET-1) in elderly women with osteosarcopenic obesity (OSO). Methods: In the present randomized clinical trial, 48 elderly women with OSO were randomly divided into a control group (n=22) and an experimental group (n=26). The subjects in the intervention group performed 12 weeks of resistance training with elastic bands three times a week. The participants became familiar with targeted number of repetitions and OMNI-resistance exercise scale to control exercise intensity. Results: The mean age, body fat percentage, body mass index (BMI), and bone mineral density T-score for the hip and L1-L4 lumbar spine of the subjects were 64.13±3.68 years, 45.4%±6.56, 33.1±3.71 kg/m2, and -1.86±1.42, respectively. After the 12-week resistance training, we observed a significant decrease in serum level of mir-92a in the experimental group compared to the control group (p=0.03). However, there was no significant difference between the study groups in terms of body weight, BMI, body fat percentage, total cholesterol, and ET-1 (p≥0.05). Conclusion: The 12-week resistance training program seems to modulate and decrease serum mir-92a expression in elderly women with OSO. The lack of a significant change in BMI, body fat percentage, and ET-1 levels following the exercise training might be due to the type and intensity of the exercises.
کلیدواژه‌های انگلیسی مقاله Resistance Training,Obesity,Sarcopenia,Osteoporosis,Aged,Vascular Stiffness
نویسندگان مقاله | Ayoub Hashemi
Department of Physical Education, Alborz Campus, University of Tehran, Tehran, Iran


| rahman soori
Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran


| Ebrahim Banitalebi
Department of Exercise Physiology, Department of Sport Sciences, Faculty of Literature and Humanities, Shahrekord University, Shahrekord, Iran


| Siroos Choobineh
Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran
نشانی اینترنتی http://mlj.goums.ac.ir/browse.php?a_code=A-10-995-1&slc_lang=en&sid=1
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده فیزیولوژی ورزشی
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