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Medical Laboratory Journal، جلد ۱۴، شماره ۵، صفحات ۳۵-۴۱
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عنوان انگلیسی The Effect of Eight-Week Aerobic Exercise before Cerebral Ischemia on the Expression of NT-3 and TrkC Genes in Male Rats
چکیده انگلیسی مقاله Background & Objective: Cerebral ischemia causes irreversible structural and functional damages in certain areas of the brain, especially the hippocampus. Evidence indicates that physical exercise may reduce the damages caused by cerebral ischemia. The purpose of this study was to examine the effect of 8-week exercise preconditioning on the expression of NT-3 and TrkC genes in the CA1 region of the hippocampus after the cerebral ischemic-reperfusion in male rats. Methods: Twenty-one male Wistar rats weighing 250-300 gr were randomly selected and divided into three groups (healthy control, control + ischemia and exercise + ischemia). Rats in the exercise group ran on a treadmill 5 days per week for 8 weeks. Ischemia by occlusion of both common carotid arteries (CCA) was created for 45 minutes. In order to evaluate the gene expression, Real time PCR technique was used. Findings: NT-3 gene expression was significantly different between exercise + ischemia with control + ischemia groups and control + ischemia with healthy control groups (P < 0.05), and TrkC gene expression was significantly different between exercise + ischemia with healthy control groups and control + ischemia with healthy control groups (P < 0.05). Conclusion: The results of this study demonstrated that exercise before the induction of ischemic stroke increased the NT-3 gene expression but did not influence the TrKC gene expression.  
کلیدواژه‌های انگلیسی مقاله Aerobic Exercise, Cerebral Ischemia, Neurotrophin 3 (NT-3), tyrosine kinase C (TrkC)
نویسندگان مقاله | Mohtaram Yazdanian
MSc of exercise physiology, Department of Physical Education and Sport Sciences, , Islamic Azad University, Bojnourd Branch, Bojnord , Iran


| Mahtab Moazzami
Associate Professor in Sport Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran


| Mohammad Shabani
Department of Sport Sciences, University of Bojnord, Bojnord, Iran


| Sadegh Cheragh Birjandi
Department of Sport Sciences, Islamic Azad University, Bojnourd Branch, Bojnourd, Iran
نشانی اینترنتی http://mlj.goums.ac.ir/browse.php?a_code=A-10-752-2&slc_lang=en&sid=1
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده فیزیولوژی ورزشی
نوع مقاله منتشر شده تحقیقی
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