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Caspian Journal of Internal Medicine، جلد ۱۲، شماره ۲، صفحات ۱۹۴-۱۹۹
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عنوان انگلیسی Effect of a synbiotic on functional abdominal pain in childhood
چکیده انگلیسی مقاله Background: One of the common functional gastrointestinal disorders in children is functional abdominal pain (FAP). The aim of the present study was to determine whether the administration of a synbiotic composed of fructo-oligosaccharides (FOS) and the seven types of beneficial bacteria is useful in FAP of childhood. Methods: In this placebo-controlled, double-blind trial, 4-15-year-old children who met the Rome III criteria for FAP were randomly divided to receive either synbiotic or placebo twice daily for 4 weeks. Primary outcome was at least 50% reduction in the number of pain episodes, and secondary outcomes were a decline of at least two scales in the pain duration and intensity based on Wong-Baker scale. Response to therapy was decrease of pain frequency/intensity. Results: A total of 67 children completed the trial (35 with synbiotic). Response rate was higher with synbiotic than placebo after four weeks (53.1 vs 11.4%; p< 0.001), and synbiotic had significant superiority to placebo to relieve the duration (4.56±9.12 vs12±18.59, min/day, P=0.04), frequency (0.31±0.53vs 1.17±0.7, episode/Wk., P<.001) and intensity (2.38±2.29 vs 5.49±1.83, p< 0.001) of abdominal pain. Conclusion: Synbiotic compared to placebo significantly decreased the intensity, frequency and duration of FAP in children.
کلیدواژه‌های انگلیسی مقاله Abdominal pain, Child, Synbiotic.
نویسندگان مقاله | Azade Gholizadeh
Student Research Committee, Babol University of Medical Sciences, Babol, Iran


| Sanaz Mehrabani
Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran


| Mohammadreza Esmaeili Dooki
Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran


| Mahmood Haji Ahmadi
Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
نشانی اینترنتی http://caspjim.com/browse.php?a_code=A-10-1437-2&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Gastroentrology
نوع مقاله منتشر شده Original Article
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