این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Middle East Journal of Cancer، جلد ۱۳، شماره ۱، صفحات ۵۷-۶۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Prognostic Value of IMP3 and Cyclin D1 Expression in Patients with Colorectal Cancer
چکیده انگلیسی مقاله Background: Colorectal cancer (CRC) is known to be the third most frequently diagnosed cancer and the fourth leading cause of cancer death worldwide. In Egypt, colorectal carcinoma is considered the 7th prevalent cancer, accounting for 3.47% of male cancers and 3% of female malignancies. A localized CRC can be entirely cured via surgical resection. Metastasis remains the leading cause of cancer mortality. IMP3 is an independent prognostic biomarker that expects metastasis and poor prognosis in CRC. The upregulation of nuclear cyclin D1 plays an essential role in pathogenesis and metastases of CRC. We aimed to investigate the expression of IMP3 and cyclin D1 in colorectal carcinoma and their correlation with other clinicopathological features. Method: In this retrospective cohort study, 80 formalin-fixed and paraffin-embedded blocks of CRC were obtained from the subjects. The immunohistochemical expression of IMP3 and cyclin D1 were examined and found to be correlated with clinical-pathological parameters and the outcome of the patients. Results: Overexpression of IMP3 and cyclin D1 was noted in 68.75% and 56.25%, respectively. IMP3 expression was significantly correlated with tumor grade (P < 0.001), tumor, node, and metastases (TNM) stage (P = 0.040), and lymphovascular invasion (P = 0.005); cyclin D1 was significantly associated with TNM stage (P < 0.001), lymph node (LN) metastasis (P < 0.001), and distant metastasis (DM) (P = 0.004); cyclin D1 was significantly correlated with TNM stage (P < 0.001), LN metastasis (P < 0.001), and DM (P = 0.004). Conclusion: IMP3 and cyclin d1 were associated with poor prognosis in CRC, w hich makes them attractive targets for anticancer drug development.
کلیدواژه‌های انگلیسی مقاله IMP3, Cyclin D1, Colorectal cancer, Recurrence, Survival
نویسندگان مقاله Salem Youssef Mohamed |
Gastroenterology and Hepatology Unit, Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Abeer Hafez |
Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Amira Elwan |
Clinical Oncology Department, Zagazig University, Zagazig, Egypt

Mohamed I. Abdelhamid |
General Surgery Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Nabila Hassan Ahmed |
Tropical Medicine Department, Zagazig University, Zagazig, Egypt

Bader A. Abdelmaksoud |
Clinical Oncology Department, Zagazig University, Zagazig, Egypt

Abeer M Abdelbary |
Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

نشانی اینترنتی https://mejc.sums.ac.ir/article_47567_138f41f8830d099947f845cf2f028ce4.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات