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Middle East Journal of Cancer، جلد ۱۳، شماره ۱، صفحات ۸۱-۸۸
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عنوان انگلیسی Association between Plasma 25-Hydroxyvitamin D and Breast Cancer Risk: A Matched Case-Control Study
چکیده انگلیسی مقاله Background: The protective role of vitamin D in the occurrence of breast cancer is nowadays a controversial matter. Based on conflicting results of the studies in this field and also considering the prevalence of vitamin D deficiency in Iranian women, this work was conducted to evaluate the association between vitamin D and breast cancer. Method: This matched case-control study was conducted on 70 newly diagnosed breast cancer patients and 70 controls with the same age, menopause status, and time of blood sampling in Zanjan. Information regarding demographic, reproductive, history of diseases, medication, use of dairy products, and sunlight exposure was collected using a questionnaire. The serum level of vitamin D was measured with ELISA method. The data were analyzed utilizing chi-square test, independent t-test, and odds ratios using conditional logistic regression model. Results: The mean level of vitamin D was 39.04 and 63.34 ng/ml in the cases and controls, respectively (P=0.046). The proportion of the cases in the highest quartile of vitamin D was significantly smaller than that in the controls compared with the lowest quartile (Ptrend=0.028). Using conditional logistic regression model, an inverse and independent association was observed between vitamin D and breast cancer after controlling main confounders. The risk of breast cancer was independently associated with body mass index and low income. Conclusion: In this study, an inverse association was confirmed between vitamin D and breast cancer. Prospective intervention studies should be performed to explore its role in the prevention of breast cancer.
کلیدواژه‌های انگلیسی مقاله Vitamin D, Breast neoplasms, Case-control
نویسندگان مقاله Flor Fakour |
Department of Surgery, Zanjan University of Medical Sciences, Zanjan, Iran

Minoosh Moghimi |
Department of Hematology-Oncology, School of Medicine, Zanjan, University of Medical Sciences, Zanjan, Iran

Abdolreza Esmaeilzadeh |
Department of Immunology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

Faranak Kalantari |
Social Determinants of Health Research Center, Zanjan University of Medical Sciences, Zanjan, Iran

Fatemeh Eskandari |
Social Determinants of Health Research Center, Zanjan University of Medical Sciences, Zanjan, Iran

Sajjad Biglari |
Social Determinants of Health Research Center, Zanjan University of Medical Sciences, Zanjan, Iran

Saeideh Mazloomzadeh |
Department of Epidemiology and Statistics, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

نشانی اینترنتی https://mejc.sums.ac.ir/article_47543_5e90686eb70818b1fe8eb8a0a975594e.pdf
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