این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Middle East Journal of Cancer، جلد ۱۳، شماره ۱، صفحات ۱۱۰-۱۱۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Does the Chemotherapy Protocol Affect CXCL12/CXCR4 Axes in Acute Myeloid Leukemia Patients with Monocytic Differentiation?
چکیده انگلیسی مقاله Background: The CXCR4 receptor along with CXCL12 is believed to have an effect on the onset, progression, migration, and treatment complications and improve acute myeloid leukemia (AML) treatment outcomes. In this study, we investigated the impact of (7+3) chemotherapy protocol on the expression of CXCR4 and its related ligand CXCL12. Method: In this case-control study, specimens were collected before and after the first cycle of chemotherapy of AML-M4 and AML-M5 patients. Reverse transcription polymerase chain reaction (RT-PCR) and flow cytometry techniques tested the CXCR4 expression. ELISA was used for measuring the serum level of CXCL12. Two samples, t-test and paired t-test, were utilized for data analysis. Results: We found that CXCR4 expression by lymphocyte cells after chemotherapy was approximately similar to the CXCR4 expression in the healthy subjects. Moreover, CXCR4 expression was high prior to chemotherapy. The serum level of CXCL12 considerably increased in the patients before chemotherapy. However, after chemotherapy, CXCL12 was found to reach the baseline level in comparison to the healthy control group. Conclusion: The (7+3) current chemotherapy inhibited CXCL12. Therefore, controlling chemokines along with chemotherapy in AML patients might be conducive to the treatment process or even prevent the relapse of the disease.
کلیدواژه‌های انگلیسی مقاله Acute myeloid leukemia, Chemotherapy, Chemokine, CXCL12, CXCR4
نویسندگان مقاله Bahar Yazdani |
Department of Hematology and Medical Laboratory Sciences, Faculty of Allied Medicine, Kerman University of Medical Sciences, Kerman, Iran

Zahra Mousavi |
Department of Hematology and Medical Laboratory Sciences, Iranshahr University of Medical Sciences, Iranshahr, Iran

Mohsen Ehsan |
Department of Hematology and Medical Laboratory Sciences, Faculty of Allied Medicine, Kerman University of Medical Sciences, Kerman, Iran

Behjat Kalantary Khandany |
Department of Hemato-Oncology, Kerman University of Medical Sciences, Kerman, Iran

Gholamhossein Hassanshahi |
Molecular Medicine Research Center, Institute of Basic Medical Sciences, Research, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

نشانی اینترنتی https://mejc.sums.ac.ir/article_47611_9da53ca2ff83846862be43c386bd82bb.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات