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Middle East Journal of Cancer، جلد ۱۳، شماره ۱، صفحات ۱۵۰-۱۵۸
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عنوان انگلیسی The Effects of Prognostic Factors on Metastasis and Survival of Patients with Breast Cancer Using a Multi-State Model
چکیده انگلیسی مقاله Background: The multi-state models help more closely study of the factors affecting the survival of patients with breast cancer. Method: We conducted the present retrospective cohort study on 2030 Iranian patients with breast cancer in 2020. The patients’ follow-up period ranged from 1 month to 15 years. Accordingly, the initial treatment, metastasis, and death were considered as the first, second, and absorbing states, respectively. The multi-state model was utilized for modeling and analyzing the data at a 95% significance level using the MSM package in R software. Results: The mean age (± standard deviation) of the patients included at diagnosis time was 55.3 (±12.07) years old. The first one year and 5 years adjusted transition probabilities for transitions from the treatment to metastasis estimated as 0.85 (0.15 – 0.89) and 0.45 (0.21 – 0.61), and for metastasis to death transitions, they were estimated as 0.15 (0.1 – 0.21) and 0.55 (0.41 - 0.69), respectively. Moreover, the average sojourn times were estimated as 0.27 and 74.85 months for the treatment and metastasis states, respectively. Conclusion: The obtained results revealed that over time, the transition probabilities of patients from surgery to metastasis state decreased, whereas the transition probabilities from metastasis to death state increased using the multi-state model.
کلیدواژه‌های انگلیسی مقاله Multi-state model, Prognostic factors, Survival analysis, Breast cancer
نویسندگان مقاله Ebrahim Babaee |
Preventive Medicine and Public Health Research Center, Psychosocial Health Research Institute, Community and Family Medicine Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Nahid Nafissi |
Breast Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Arash Tehrani-Banihashemi |
Preventive Medicine and Public Health Research Center, Psychosocial Health Research Institute, Community and Family Medicine Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Babak Eshrati |
Preventive Medicine and Public Health Research Center, Psychosocial Health Research Institute, Community and Family Medicine Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Leila Janani |
Preventive Medicine and Public Health Research Center, Psychosocial Health Research Institute, Community and Family Medicine Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Marzieh Nojomi |
Preventive Medicine and Public Health Research Center, Psychosocial Health Research Institute, Community and Family Medicine Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

نشانی اینترنتی https://mejc.sums.ac.ir/article_47478_2601fbaf045717df01e3a6c138d44ba4.pdf
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