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Middle East Journal of Cancer، جلد ۱۲، شماره ۲، صفحات ۲۶۱-۲۶۸
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عنوان انگلیسی Phycocyanin C a Natural Product with Impressive Therapeutic Efficacy for Inhibition of Breast Tumors’ Growth and Metastasis in Vivo
چکیده انگلیسی مقاله Background: Several studies have reported the anticancer effect of phycocyanin C, a natural extract isolated from the algae Arthrospira platensis. However, its therapeutic effects on the growth of breast cancer and its metastasis have not been determined yet. Method: In this case-control study, we employed phycocyanin C for the treatment of 4T1 breast tumor as an applicable experimental animal model for human mammary cancer and metastasis. BALB/c mice were injected subcutaneously (s.c) into the 4th abdominal mammary fat pad with 1×106 4T1 cells. We randomly divided the mice into two groups; one group of mice were injected with PBS as the control, and the other group was intraperitoneally injected with phycocyanin C (80 mg/kg daily for 20 days). Tumor growth and metastasis were assessed in both groups. Results: Phycocyanin C significantly inhibited 4T1 breast tumors growth (P< 0.05). The mean tumors volumes at the control group were 2.73 times higher than those of the treatment group. In addition, phycocyanin C treatment could significantly inhibit the formation of metastasis colonies at vital organs like spleen, liver, and lung. Moreover, the survival rate of the tumor-bearing mice increased after about 22 days by phycocyanin C treatment in comparison with the control. Conclusion: This is the first report demonstrating the anticancer effects of phycocyanin C on 4T1 breast tumor in vivo. Overall, our findings provided convincing evidence for the application of phycocyanin C as an anticancer therapeutic agent.
کلیدواژه‌های انگلیسی مقاله Phycocyanin C, Breast Neoplasm, Metastasis
نویسندگان مقاله Amirhosein Kefayat |
Department of Oncology, Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Mohadeseh Yuosefzadeh |
Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Parvin Goli |
Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Alireza Babayi |
Department of Biology, Payame Noor Isfahan University, Isfahan, Iran

Abbas Rezaei |
Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Nafiseh Esmaeil |
Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

نشانی اینترنتی https://mejc.sums.ac.ir/article_47014_0033ae7be4271f1d63c241b8fc17a031.pdf
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