این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Middle East Journal of Cancer، جلد ۱۲، شماره ۱، صفحات ۴۰-۴۷
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Expression Changes of miR-146a-5p and miR-196a-2 in Non-small Cell Lung Cancer Patients: A Case-control Study
چکیده انگلیسی مقاله Background: Recent evidence underscores to the important regulatory roles of microRNAs as a biomarker for diagnosis of non-small cell lung cancer (NSCLC); this disease often has poor prognosis, and it is the most prevalent cause of cancer-related mortality worldwide. This study investigated the levels of miR-146a-5p and miR-196a-2 in peripheral blood mononuclear cells (PBMC). Methods: In the present case-control research, we collected the PBMCs through isolating blood from 22 NSCLC patients and 22 healthy individuals. Following the extraction of total RNA and cDNA synthesis, we studied the expression levels of miR-146a and miR-196a-2 by using qPCR. Results: Both the miR-146a-5p and miR-196a-2 were significantly down-regulated in the PBMCs of NSCLC patients in comparison with normal healthy ones (P=0.002 and p < 0.001, respectively). There was an association between the expression levels of microRNAs and the types of tumors, which was significant for miR-146a-5p (P=0.02). Furthermore, in NSCLC cases, a significant positive correlation existed between miR-196a-2 and miR-146a-5p expression levels (r=0.71, P=0.002). Conclusion: According to the study results, miR-146a-5p and miR-196a-2 that were down-regulated in the PBMCs of NSCLC patients might serve as potential biomarkers for diagnosis if confirmed in future studies.
کلیدواژه‌های انگلیسی مقاله Non-small-cell lung, Carcinoma, miR-146a, miR-196a-2
نویسندگان مقاله Shirin Vafadar |
Department of Biochemistry, Higher Education Institute of Rab-e Rashidi, Tabriz, Iran

Venus Zafari |
Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Masoud Pour Moghaddam |
Mt Kuring-Gai Medical Centre, NSW, Australia

Milad Assadi |
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Soltan Ali Mahboob |
Department of Biochemistry, Higher Education Institute of Rab-e Rashidi, Tabriz, Iran

Akbar Sharifi |
Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Ensiyeh Seyedrezazadeh |
Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

نشانی اینترنتی https://mejc.sums.ac.ir/article_46823_00508182a828782af00d713b1806f1b0.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات