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Middle East Journal of Cancer، جلد ۱۲، شماره ۱، صفحات ۶۹-۷۸
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عنوان انگلیسی An Investigation of the Pathology Report of Prostate Cancer Patients with Radical Prostatectomy in Southern Iran: A Cross-sectional Study
چکیده انگلیسی مقاله Background: Prostate cancer is a major malignancy worldwide among men; it is the fourth leading cancer in both genders. This study investigated the pathologic factors of radical prostatectomy (RP) specimens. Method: About 578 men underwent RP during five years in Shiraz University hospitals. We recorded the following clincopathological parameters: tumor type and stage, Gleason score (GS), grade, tertiary pattern, ISUP, surgical margin, lymph node (LN) involvement, lymphovascular invasion, seminal vesicle involvement, extraprostatic extension (EPE), vas deferens invasion, perineural and pseudocapsular invasion, bladder neck involvement, and age. Results: The mean age of participants was 63.87 ± 6.95 years. Most had pathologic T2N0Mx (73 %) diseases; the most GS was low-risk GS ≤ 6 (47.4%). Surgical margin status was free of tumors in 72.5% and among those with positive margins; the most involved site was the apex in 18.3%. Single and dual LN involvements were the most prevalent patterns. 5.9% of the patients had EPE. We found perineural and pseudocapsular invasions in 59.9% and 29.9%, respectively. There was a strong correlation between the clincopathological parameters, stage, and ISUP. Perineural invasion, pseudocapsular invasion, and tertiary pattern 5 increased with advanced age (P < 0.0001). The GS 8 to 10 increased with the increase in age (P =0.001). Conclusion: A strong correlation existed between the clincopathological parameters, stage, and ISUP. Additionally, perineural and pseudocapsular involvement and tertiary pattern 5 had a strong relationship with advanced age.
کلیدواژه‌های انگلیسی مقاله Prostate Cancer, Radical prostatectomy, Pathology
نویسندگان مقاله Ali Ariafar |
Department of Urology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Shahryar Zeighami |
Department of Urology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Mehdi Salehipour |
Department of Urology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Faisal Ahmed |
Department of Urology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Zahra Shahabi |
Department of Urology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Hossein-Ali Nikbakht |
Social Determinates of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran

نشانی اینترنتی https://mejc.sums.ac.ir/article_46813_62b0965de55ee33cad15ceb9ea36a3a5.pdf
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