این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Middle East Journal of Cancer، جلد ۱۲، شماره ۱، صفحات ۱۴۷-۱۵۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effect of Lutein-Rich Extract on Human Cancer Cells
چکیده انگلیسی مقاله Background: Lutein and its isomerzeaxanthin are safe natural compounds. They are able to reduce the development of tumor and other chronic diseases. The objectives of the current study was to examine the cytotoxicity of lutein isolated and purified from alfalfa, safe and low-cost plant, on five different human cancer cell lines, namely (MCF-7), (HepG2), (A549), (PC3), and (HCT116), as well as normal (HFB4) cells. Method: We examined the cytotoxicity of lutein purified from Medicago sativa L and evaluate its activity against human liver HepG2, breast MCF-7, lung A549, prostate PC3, and colon HCT116 cancer cell lines using SRB assay in comparison with doxorubicin as a reference drug. Results: Results revealed that the tested extract could be a more promising anticancer agent in the case of MCF-7 (IC50, 3.10±0.47 μg/ml) compared with standard drug doxorubicin (IC50, 2.90±0.30 μg/ml). Moreover, the extract showed a moderate effect on HepG2 (IC50, 6.11±0.84 μg/ml) versus doxorubicin (IC50, 2.90±0.30 μg/ml); meanwhile, the extract showed no activity against A549, PC3, and HCT116 cells. The results further revealed that the extract had no toxicity against the growth of normal HFB4 cells versus doxorubicin. Conclusion: Lutein-rich extract from alfalfa had a major antiproliferative role in breast MCF-7 and liver HepG2 compared to doxorubicin.
کلیدواژه‌های انگلیسی مقاله Carotenoids, Medicago sativa L, Alfalfa, Cytotoxicity, Anticancer
نویسندگان مقاله Wesam Mostafa Omar |
Biotechnology and Life Sciences Department, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni-Suef, Egypt

Amr E. Ahmed |
Biotechnology and Life Sciences Department, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni-Suef, Egypt

Mai Raslan |
Biotechnology and Life Sciences Department, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni-Suef, Egypt

Khalid El-Nesr |
Pathology Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, Egypt

Mamdouh Moawad Ali |
Biochemistry Department, National Research Centre, Cairo, Egypt

Mohamed De Abdelmaksoud |
Biochemistry Department, National Research Centre, Cairo, Egypt

Dina El Dahshan |
Clinical Pathology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt

نشانی اینترنتی https://mejc.sums.ac.ir/article_46802_50263b760ebf677b5554d407514a6913.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات