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Middle East Journal of Cancer، جلد ۱۱، شماره ۴، صفحات ۴۴۵-۴۵۳
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عنوان انگلیسی The Relationship of XPA and XPC Gene Polymorphisms with the Risk of Colorectal Cancer in Iran
چکیده انگلیسی مقاله Background: The objective of this study was to investigate the effect of several XPA and XPC polymorphisms on the risk of colorectal cancer (CRC) in northeastern Iran. Method: 180 CRC patients and 160 healthy subjects participated in this case-control study. We determined the genotypes by RFLP-PCR and PIRA-PCR, and analyzed the results using logistic regression and χ2-test. Results: Our findings showed that only BMI could affect the risk of cancer among the studied demographic factors. Three of the four polymorphisms studied, namely XPA A23G, XPC rs2228000 C > T and XPC rs2228001 A > C, did not correlate with CRC (P-values > 0.05); however, the polymorphism of XPC poly AT (PAT) increased the risk of CRC (P= 0.024). The XPC rs2228000 C> T polymorphism increased the CRC risk only in patients aged 50 or more. The risk of CRC in heterozygote individuals (XPC PAT D/I) was higher than that of homozygous individuals (XPC PAT D/D); also, at least one PAT I variant allele increased the likelihood of CRC (for PAT D/I OR =2.168; 95% CI = 1.809-4.319: and for PAT D/I and PAT I/I OR = 1.810; 95% CI = 1.165-2.813). The XPC haplotypes were similar between the cases and controls, and P-values were >0.05. Conclusion: In the whole population, XPC PAT polymorphism, overweightness, and XPC rs2228000 C>T polymorphism in elderly people are related to CRC. Therefore, they can probably be considered as markers of CRC in Iran.
کلیدواژه‌های انگلیسی مقاله XPA, XPC, Polymorphism, Colorectal cancer
نویسندگان مقاله Jamshid Mehrzad |
Department of Biochemistry, Neyshabur Medical Sciences Branch, Islamic Azad University, Neyshabur, Iran

Mahdieh Dayyani |
Radiation Oncology Department, Reza Radiotherapy Oncology Center, Mashhad, Iran

Mohamadreza Erfanian-Khorasani |
Department of Biochemistry, Neyshabur Medical Sciences Branch, Islamic Azad University, Neyshabur, Iran

نشانی اینترنتی https://mejc.sums.ac.ir/article_46780_d614eb0f99dd0f54ee5f70bf3301a34b.pdf
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