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Middle East Journal of Cancer، جلد ۱۱، شماره ۴، صفحات ۴۷۶-۴۸۲
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عنوان انگلیسی SS18-SSX Rearrangement in Synovial Sarcoma Using Fluorescent in Situ Hybridization: A Report from an Iranian Population and Literature Review
چکیده انگلیسی مقاله Background: Synovial sarcoma is an aggressive soft tissue sarcoma. It has a wide spectrum of histopathologic patterns and uncertain immunohistochemistry, rendering it a diagnostic challenge. The objective of this study was to investigate the diagnostic utility and impact of SS18-SSX rearrangement evaluation in an Iranian population previously diagnosed with synovial sarcoma without such molecular tests. Method: We conducted this cross-sectional study on 44 formalin-fixed paraffin-embedded tissue blocks obtained from 23 synovial sarcoma patients (males, 69%; mean age, 36.4 years) and 11 cases with other neoplasms as negative controls. We assessed these specimens for SSX-SS18 gene rearrangement by break-apart fluorescent in situ hybridization (FISH) probes. Results: FISH study showed SS18-SSX fusion gene in 17 (73.91%) cases while six (26.09%) cases and negative controls did not show SS18-SSX fusion. Histopathologic type of tumor was significantly related to the presence of rearrangement (P=0.002) (rearranged: 11 biphasic and six monophasic tumors; non-rearranged: three monophasic and three poorly-differentiated tumors). Conclusion: This study supports the idea that molecular studies contribute to the confirmation of synovial sarcoma diagnosis, particularly in monophasic and poorly-differentiated subtypes, which show vague immunohistochemical results.
کلیدواژه‌های انگلیسی مقاله Synovial sarcoma, Gene fusion, Fluorescent in situ hybridization, SS18-SSX1 fusion protein
نویسندگان مقاله Akbar Safaei |
Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran

Elham Jansar |
Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran

Ahmad Monabati |
Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran

Maral Mokhtari |
Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran

Mehdi Montazer |
Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran

نشانی اینترنتی https://mejc.sums.ac.ir/article_46787_039552932907cbbeea16d22f5c3c36d4.pdf
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