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Journal of Family and Reproductive Health، جلد ۱۴، شماره ۱، صفحات ۳۸-۴۴
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عنوان انگلیسی Extra Virgin Olive Oil Modulates Vasodilator Enzyme Level by Repairing Angiogenesis Function in Rat Model of Preeclampsia
چکیده انگلیسی مقاله Objective: This study aimed to determine the effect of Extra Virgin Olive Oil (EVOO) on vasodilator enzyme by repairing angiogenic function in rat model of preeclampsia. Materials and methods: This research consisted of five groups; negative control (normal pregnant rats) group, positive control (preeclampsia rat model) group, preeclampsia rat model groups given EVOO in 3 different doses (0.5 ml/day, 1 ml/day, and 2 ml/day, respectively). Blood pressure measurements were carried out on day 12, 15, and 19 of pregnancy. After the rats were sacrificed, the placentas were collected to determine endothelial Nitric Oxide Synthase (eNOS) level of maternal plasma to determine soluble Fms-like Tyrosine Kinase 1 (sFlt-1) and Vascular Endothelial Growth Factor (VEGF) level. Results: There were significant higher sFlt-1 level (p < 0.001), lower VEGF level (p = 0.009), and lower eNOS level (p = 0.034) between negative and positive control groups. After EVOO administration, sFlt-1 level was lower in dose 1 and 2 groups but higher in dose 3 group in accordance with VEGF and eNOS levels that were increasing both in dose 1 and dose 2 groups but decreasing in dose 3. There were significant differences between positive control and dose 1 (p = 0.015) and dose 2 (p = 0.001) in sFlt-1 level. None of all dose groups were statistically different with positive control group in VEGF level (dose 1 p = 0.601; dose 2 p = 0.297; dose 3 p = 0.805). eNOS levels of all dose groups were statistically different from that of the positive control group (dose 1 p = 0.014; dose 2 p = 0.001; dose 3 p = 0.024). Conclusion: Administration of EVOO modulates eNOS as vasodilator enzyme by repairing the angiogenic function indicated by decreased sFlt-1 level and increased VEGF in rat model of preeclampsia.
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نویسندگان مقاله | Yulia Silvani
Midwifery Department, Faculty of Medicine, University of Brawijaya, Malang, Indonesia


| Agnestia Dian Lovita
Midwifery Department, Faculty of Medicine, University of Brawijaya, Malang, Indonesia


| Afniari Maharani
Midwifery Department, Faculty of Medicine, University of Brawijaya, Malang, Indonesia


| I Wayan Wiyasa
Department of Obstetrics and Gynecology, Dr. Saiful Anwar General Hospital, Malang, Indonesia


| Hidayat Sujuti
Department of Biochemistry-Molecular Biology, Faculty of Medicine, University of Brawijaya, Malang, Indonesia


| Retty Ratnawati
Department of Physiology, Faculty of Medicine University of Brawijaya, Malang, Indonesia


| Tri Yudani Raras
Department of Biochemistry-Molecular Biology, Faculty of Medicine, University of Brawijaya, Malang, Indonesia
نشانی اینترنتی https://jfrh.tums.ac.ir/index.php/jfrh/article/view/1227
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