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Basic and Clinical Neuroscience، جلد ۱۲، شماره ۱، صفحات ۴۳-۵۶
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چکیده فارسی مقاله
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عنوان انگلیسی Paeonol Protection Against Intrastriatal 6-Hydroxydopamine Rat Model of Parkinson's Disease
چکیده انگلیسی مقاله Introduction: Parkinson's disease (PD) presentations comprise frequent movement disorders in the elderly with various symptoms consisting of motor and non-motor complications. Paeonol is a phenolic chemical agent that has shown antioxidant and anti-inflammatory effects in different disorders and promising effects on metabotropic glutamate receptors (mGluR)- and GABAA-mediated neurotransmission. In this research, we tried to show the neuroprotective potential of paeonol in rat PD model induced by intrastriatal 6-hydroxydopamine (6-OHDA). Methods: Rats with intrastriatal 6-OHDA lesioning received with paeonol at a dosage of 100 mg/kg/d for one week. In the end, some biomarkers of oxidative stress, apoptosis, and astrogliosis in nigral and striatal tissues were evaluated in addition to behavioral and Tyrosine Hydroxylase (TH) immunohistochemical analysis. Results: The obtained data showed that paeonol alleviates apomorphine-induced rotations and reduces the delay time to initiate and the total time in the narrow beam test. However, its beneficial behavioral effect vanished after intracerebroventricular administration of mGluR III or GABAA receptor antagonists. Moreover, paeonol significantly restored striatal malondialdehyde, tissue levels of reactive oxygen species, the activity of the protective and vital enzymes consisting of superoxide dismutase and catalase, Glial Fibrillary Acidic Protein (GFAP), DNA fragmentation, phosphor apoptosis signal-regulating kinase 1, and nigral aquaporin 4 with no significant and proper change of nitrite, interleukin-1β, inducible nitric oxide synthase, and angiotensin II. Additionally, paeonol prevented injury and reduced tyrosine hydroxylase-containing neurons in the midbrain nigral tissue. Conclusion: These obtained findings evidently designate neuroprotective property of paeonol in 6-OHDA murine model of PD that is exerted via easing of oxidative stress, apoptosis, astrogliosis, and its advantageous effect is to some extent mediated via mGluR III/GABAA pathway.
کلیدواژه‌های انگلیسی مقاله Paeonol, 6-hydroxydopamine, Oxidative stress, Apoptosis, GABA receptor, Metabotropic glutamate receptor
نویسندگان مقاله | Jamileh Ghalami
Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.


| Tourandokht Baluchnejad Mojarad
Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.


| Monireh Mansouri
Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.


| Safoura Khamse
Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.


| Mehrdad Roghani
Neurophysiology Research Center, Shahed University, Tehran, Iran.
نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-88-7&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Behavioral Neuroscience
نوع مقاله منتشر شده Original
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